iPTMnet Report for P51580 (TPMT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51580 / TPMT_HUMAN
Protein Name Thiopurine S-methyltransferase
Gene Name Name: TPMT
Organism Homo sapiens (Human)

PRO ID PR:P51580
DAG View
PRO Name thiopurine S-methyltransferase (human)
Definition A thiopurine S-methyltransferase that is encoded in the genome of human.
Short Label hTPMT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51580 (TPMT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 20230923, 19664994, ...18452278, 19651622, 18669648, 19690332, 24275569, 20166139, 19415658, 20068231
T16 Phosphorylation HPRD   PhosphoSitePlus 18767875
T25 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K58 Acetylation PhosphoSitePlus   UniProt 19608861
K58 Ubiquitination PhosphoSitePlus
C70 Methylation IEDB 31844290
K77 Acetylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K37 N37 Biomuta DOID:363 / uterine cancer [ icgc ]
C70 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K176 N176 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]