iPTMnet Report for P51532 (SMARCA4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51532 / SMCA4_HUMAN
Protein Name Transcription activator BRG1
Gene Name Name: SMARCA4
Synonyms:BAF190A,BRG1,SNF2B,SNF2L4;
Organism Homo sapiens (Human)

PRO ID PR:P51532
DAG View
PRO Name transcription activator BRG1 (human)
Definition A transcription activator BRG1 that is encoded in the genome of human.
Short Label hSMARCA4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51532 (SMARCA4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus   UniProt 17081983
S31 Phosphorylation PhosphoSitePlus   RLIMS-P 30177679
S35 Phosphorylation PhosphoSitePlus   RLIMS-P 30177679
R181 Methylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus   UniProt 19608861
R192 Methylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S297 O-Glycosylation GlyGen 33214551, 34725712, 35138101, ...32522876, 34019948, 32119511, 35289036, 28510447, 34229054
T298 O-Glycosylation GlyGen 33214551, 34725712, 35138101, ...32522876, 34019948, 32119511, 35289036, 28510447, 34229054
T298 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus   UniProt 19690332
K357 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K437 Methylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K461 Acetylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
R529 Methylation PhosphoSitePlus
Y538 Phosphorylation PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
T609 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S610 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648, 19690332
S613 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569, ...19690332
S624 Phosphorylation PhosphoSitePlus
K626 Acetylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
T681 Phosphorylation PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
S695 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...19690332, 20068231
S699 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
K711 Ubiquitination PhosphoSitePlus
Y718 Phosphorylation PhosphoSitePlus
S721 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 24413084
S721 Phosphorylation Q13315 (ATM) PhosphoSitePlus 24413084
Y732 Phosphorylation PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
K1014 Ubiquitination PhosphoSitePlus
K1029 Acetylation PhosphoSitePlus
K1033 Acetylation PhosphoSitePlus
K1081 Ubiquitination PhosphoSitePlus
R1087 Methylation PhosphoSitePlus
Y1123 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
K1213 Ubiquitination PhosphoSitePlus
K1219 Acetylation PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
Y1220 Phosphorylation PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus
K1227 Sumoylation PhosphoSitePlus
K1227 Ubiquitination PhosphoSitePlus
K1237 Ubiquitination PhosphoSitePlus
K1291 Sumoylation PhosphoSitePlus
K1332 Acetylation PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
K1349 Sumoylation PhosphoSitePlus
K1349 Ubiquitination PhosphoSitePlus
T1358 Phosphorylation PhosphoSitePlus
K1365 Ubiquitination PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
K1375 Ubiquitination PhosphoSitePlus
Y1379 Phosphorylation PhosphoSitePlus
S1380 Phosphorylation PhosphoSitePlus
S1382 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692
K1386 Ubiquitination PhosphoSitePlus
T1396 Phosphorylation PhosphoSitePlus
S1410 Phosphorylation PhosphoSitePlus
S1417 Phosphorylation PhosphoSitePlus
S1421 Phosphorylation PhosphoSitePlus
S1422 Phosphorylation PhosphoSitePlus
T1423 Phosphorylation PhosphoSitePlus
T1425 Phosphorylation PhosphoSitePlus
T1426 Phosphorylation PhosphoSitePlus
T1428 Phosphorylation PhosphoSitePlus
S1452 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 25083560, ...17081983
T1459 Phosphorylation PhosphoSitePlus
K1492 Ubiquitination PhosphoSitePlus
Y1497 Phosphorylation PhosphoSitePlus
C1533 Methylation IEDB 31844290
S1570 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S1575 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S1586 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1592 Phosphorylation PhosphoSitePlus
S1617 Phosphorylation PhosphoSitePlus
S1627 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
S1631 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
S1640 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1642 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1644 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 17081983
T609 Phosphorylation HPRD 19413330, 18669648, 17081983, ...18452278
S610 Phosphorylation HPRD 19413330, 17525332, 18669648, ...20068231, 18452278
S613 Phosphorylation HPRD 19413330, 18669648, 17081983, ...18452278
S655 Phosphorylation HPRD 17081983
S657 Phosphorylation HPRD 17081983
S660 Phosphorylation HPRD 17081983
S662 Phosphorylation HPRD 17081983
S695 Phosphorylation HPRD 19651622, 15302935, 20068231, ...18452278
S699 Phosphorylation HPRD 19651622, 20068231
S721 Phosphorylation HPRD 17525332
S1382 Phosphorylation HPRD 19413330, 15302935, 19664995, ...19691289, 19651622, 18669648, 20068231
T1384 Phosphorylation HPRD 19651622, 19691289
T1423 Phosphorylation HPRD 20068231
S1452 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S1570 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S1575 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S1586 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S1627 Phosphorylation HPRD 19651622, 18669648, 18452278
S1631 Phosphorylation HPRD 19651622, 18669648, 18452278
S1640 Phosphorylation HPRD 18669648
S1642 Phosphorylation HPRD 18669648
S1644 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K1360 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K1360 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P51532 (SMARCA4) S35 Q969H0 (FBXW7) unknown eFIP 30177679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S31 N31 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S35 L35 Biomuta DOID:1324 / lung cancer [ cosmic ]
S35 P35 Biomuta DOID:3571 / liver cancer [ cosmic ]
K188 M188 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K399 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S446 Y446 Biomuta DOID:184 / bone cancer [ cosmic ]
K502 N502 Biomuta DOID:1324 / lung cancer [ cosmic ]
T609 S609 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S624 I624 Biomuta DOID:363 / uterine cancer [ icgc ]
S662 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T681 I681 Biomuta DOID:4159 / skin cancer [ cosmic ]
K835 N835 Biomuta DOID:1324 / lung cancer [ cosmic ]
K872 N872 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K991 T991 Biomuta DOID:1324 / lung cancer [ cosmic ]
K991 E991 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K1033 N1033 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1081 T1081 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1213 N1213 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1220 D1220 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y1220 C1220 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1221 E1221 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1237 E1237 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1291 N1291 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S1345 W1345 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1345 L1345 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1358 A1358 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K1360 R1360 Biomuta DOID:8618 / oral cavity cancer [ cosmic, cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1371 Y1371 Biomuta DOID:263 / kidney cancer [ cosmic ]
T1384 M1384 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1386 N1386 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K1386 M1386 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1410 L1410 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1410 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1422 F1422 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T1423 A1423 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1452 F1452 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1592 F1592 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1617 G1617 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1617 N1617 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1640 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1644 N1644 Biomuta DOID:9256 / colorectal cancer [ icgc ]