iPTMnet Report for P51531 (SMARCA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51531 / SMCA2_HUMAN
Protein Name Probable global transcription activator SNF2L2
Gene Name Name: SMARCA2
Synonyms:BAF190B,BRM,SNF2A,SNF2L2;
Organism Homo sapiens (Human)

PRO ID PR:P51531
DAG View
PRO Name probable global transcription activator SNF2L2 (human)
Definition A probable global transcription activator SNF2L2 that is encoded in the genome of human.
Short Label hSMARCA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51531 (SMARCA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus   UniProt 24275569
S175 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K190 Acetylation PhosphoSitePlus
R194 Methylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
K333 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
K437 Acetylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
R505 Methylation PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
S587 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S588 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K604 Acetylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
Y642 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus   UniProt 23186163
S670 Phosphorylation PhosphoSitePlus
Y689 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
K842 Ubiquitination PhosphoSitePlus
C861 Methylation IEDB 31844290
S956 Phosphorylation PhosphoSitePlus
K961 Ubiquitination PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
K996 Acetylation PhosphoSitePlus
K997 Acetylation PhosphoSitePlus   UniProt 19608861
K999 Acetylation PhosphoSitePlus   UniProt 19608861
K1003 Acetylation PhosphoSitePlus
T1004 Phosphorylation PhosphoSitePlus
T1008 Phosphorylation PhosphoSitePlus
Y1020 Phosphorylation PhosphoSitePlus
Y1035 Phosphorylation PhosphoSitePlus
Y1046 Phosphorylation PhosphoSitePlus
K1051 Ubiquitination PhosphoSitePlus
R1057 Methylation PhosphoSitePlus
K1183 Ubiquitination PhosphoSitePlus
K1189 Acetylation PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
Y1190 Phosphorylation PhosphoSitePlus
K1191 Ubiquitination PhosphoSitePlus
K1197 Sumoylation PhosphoSitePlus
K1197 Ubiquitination PhosphoSitePlus
K1207 Ubiquitination PhosphoSitePlus
K1269 Acetylation PhosphoSitePlus
K1271 Acetylation PhosphoSitePlus
S1282 Phosphorylation PhosphoSitePlus
K1286 Sumoylation PhosphoSitePlus
K1286 Ubiquitination PhosphoSitePlus
T1295 Phosphorylation PhosphoSitePlus
K1302 Ubiquitination PhosphoSitePlus
S1308 Phosphorylation PhosphoSitePlus
Y1316 Phosphorylation PhosphoSitePlus
K1323 Ubiquitination PhosphoSitePlus
N1333 N-Glycosylation GlyGen 24190977
S1377 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S1408 Phosphorylation PhosphoSitePlus
S1410 Phosphorylation PhosphoSitePlus
S1418 Phosphorylation PhosphoSitePlus
S1419 Phosphorylation PhosphoSitePlus
K1434 Ubiquitination PhosphoSitePlus
Y1439 Phosphorylation PhosphoSitePlus
C1475 Methylation IEDB 31844290
S1512 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332
S1516 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332
S1528 Phosphorylation PhosphoSitePlus   UniProt 18669648
K1538 Acetylation PhosphoSitePlus
K1540 Acetylation PhosphoSitePlus
K1547 Acetylation PhosphoSitePlus
K1551 Acetylation PhosphoSitePlus
K1553 Acetylation PhosphoSitePlus
K1555 Acetylation PhosphoSitePlus
K1556 Acetylation PhosphoSitePlus
S1568 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16097034, 17081983, 20068231, ...18318008
S1572 Phosphorylation PhosphoSitePlus   UniProt 20068231, 17081983, 24275569, ...18318008
S1582 Phosphorylation PhosphoSitePlus
S1585 Phosphorylation PhosphoSitePlus
T1587 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S175 Phosphorylation HPRD 18669648, 20068231
S326 Phosphorylation HPRD 20068231
S329 Phosphorylation HPRD 17081983, 19691289, 18452278, ...19651622, 18669648, 20068231
S587 Phosphorylation HPRD 17081983
S588 Phosphorylation HPRD 17081983
S591 Phosphorylation HPRD 15302935, 18452278
S615 Phosphorylation HPRD 17081983
Y627 Phosphorylation HPRD 17081983
S640 Phosphorylation HPRD 17081983
Y642 Phosphorylation HPRD 17081983
S651 Phosphorylation HPRD 17081983
S652 Phosphorylation HPRD 17081983
S698 Phosphorylation HPRD 18669648
T882 Phosphorylation HPRD 20068231
S956 Phosphorylation HPRD 17081983
S1377 Phosphorylation HPRD 17081983
S1410 Phosphorylation HPRD 17525332
S1512 Phosphorylation HPRD 18669648, 18452278
S1516 Phosphorylation HPRD 18669648, 18452278
S1528 Phosphorylation HPRD 18669648, 18452278
S1530 Phosphorylation HPRD 18669648
S1568 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1572 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1582 Phosphorylation HPRD 18669648
S1585 Phosphorylation HPRD 18669648
T1587 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S175 Phosphorylation HPRD 18669648, 20068231
S326 Phosphorylation HPRD 20068231
S329 Phosphorylation HPRD 17081983, 19691289, 18452278, ...19651622, 18669648, 20068231
S587 Phosphorylation HPRD 17081983
S588 Phosphorylation HPRD 17081983
S591 Phosphorylation HPRD 15302935, 18452278
S615 Phosphorylation HPRD 17081983
Y627 Phosphorylation HPRD 17081983
S640 Phosphorylation HPRD 17081983
Y642 Phosphorylation HPRD 17081983
S651 Phosphorylation HPRD 17081983
S652 Phosphorylation HPRD 17081983
S698 Phosphorylation HPRD 18669648
T882 Phosphorylation HPRD 20068231
S956 Phosphorylation HPRD 17081983
S1377 Phosphorylation HPRD 17081983
T1393 Phosphorylation PhosphoSitePlus
S1400 Phosphorylation HPRD 17081983
S1401 Phosphorylation HPRD 17081983
S1406 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
S1494 Phosphorylation HPRD 18669648, 18452278
S1498 Phosphorylation HPRD 18669648, 18452278
S1510 Phosphorylation HPRD 18669648, 18452278
S1512 Phosphorylation HPRD 18669648
S1550 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1554 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1564 Phosphorylation HPRD 18669648
S1567 Phosphorylation HPRD 18669648
T1569 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S172 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K190 E190 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K190 T190 Biomuta DOID:363 / uterine cancer [ icgc ]
R194 L194 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S316 L316 Biomuta DOID:4159 / skin cancer [ cosmic ]
T408 M408 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K437 N437 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
K437 E437 Biomuta DOID:3571 / liver cancer [ cosmic ]
R505 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K604 E604 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y642 H642 Biomuta DOID:184 / bone cancer [ cosmic ]
S651 F651 Biomuta DOID:4159 / skin cancer [ cosmic ]
S666 R666 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S670 Y670 Biomuta DOID:363 / uterine cancer [ icgc ]
S820 N820 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K996 E996 Biomuta DOID:3571 / liver cancer [ cosmic ]
K996 N996 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K997 M997 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1057 H1057 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1057 C1057 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1057 S1057 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y1190 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1401 L1401 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1410 Y1410 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1419 L1419 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1494 N1494 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1510 T1510 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1512 N1512 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1512 F1512 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1528 T1528 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1530 F1530 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1555 N1555 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T1569 M1569 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
T1587 M1587 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]