iPTMnet Report for P51530 (DNA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51530 / DNA2_HUMAN
Protein Name DNA replication ATP-dependent helicase/nuclease DNA2
Gene Name Name: DNA2
Synonyms:DNA2L,KIAA0083;
Organism Homo sapiens (Human)

PRO ID PR:P51530
DAG View
PRO Name DNA replication ATP-dependent helicase/nuclease DNA2 (human)
Definition A DNA replication ATP-dependent helicase/nuclease DNA2 that is encoded in the genome of human.
Short Label hDNA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51530 (DNA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
C80 Methylation IEDB 31844290
K178 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
C218 Methylation IEDB 31844290
K219 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
C402 Methylation IEDB 31844290
Y405 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
C668 Methylation IEDB 31844290
S671 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
C893 Methylation IEDB 31844290
K908 Ubiquitination PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
K968 Ubiquitination PhosphoSitePlus
S975 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
T989 Phosphorylation PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
C1016 Methylation IEDB 31844290
K1037 Ubiquitination PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
C1051 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K207 Q207 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C218 F218 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S267 P267 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K459 N459 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K704 M704 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K704 N704 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C1016 Y1016 Biomuta DOID:5041 / esophageal cancer [ cosmic ]