iPTMnet Report for P51452 (DUSP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51452 / DUS3_HUMAN
Protein Name Dual specificity protein phosphatase 3
Gene Name Name: DUSP3
Synonyms:VHR;
Organism Homo sapiens (Human)

PRO ID PR:P51452
DAG View
PRO Name dual specificity protein phosphatase 3 (human)
Definition A dual specificity protein phosphatase 3 that is encoded in the genome of human.
Short Label hDUSP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51452 (DUSP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation neXtProt   PhosphoSitePlus 12447358
Y38 Phosphorylation P43403 (ZAP70) neXtProt   PhosphoSitePlus 12447358
Y38 Phosphorylation P43405 (SYK) PhosphoSitePlus 12447358
K50 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
Y138 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12447358, 17785772
Y138 Phosphorylation P29597 (TYK2) Signor 17785772
Y138 Phosphorylation P43403 (ZAP70) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12447358
Y138 Phosphorylation P43405 (SYK) phospho.ELM   PhosphoSitePlus 12447358
S149 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 18491316
Y38 Phosphorylation HPRD 20068231
T133 Phosphorylation HPRD 20068231
Y138 Phosphorylation HPRD 12447358
Y138 Phosphorylation P43403 (ZAP70) HPRD 12447358


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K50 R50 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T133 M133 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]