iPTMnet Report for P51451 (BLK)
Protein Information
| UniProt AC / UniProt ID | P51451 / BLK_HUMAN |
| Protein Name | Tyrosine-protein kinase Blk |
| Gene Name | Name: BLK |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P51451 |
| PRO Name | tyrosine-protein kinase Blk (human) |
| Definition | A tyrosine-protein kinase BLK that is encoded in the genome of human. |
| Short Label | hBLK |
| Category | organism-gene |
DAG ViewP51451 (BLK) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y107 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K144 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K157 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K165 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K175 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y187 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y188 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S197 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y205 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K208 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K272 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y309 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y314 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K325 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S341 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y350 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S356 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K375 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y389 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K396 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C460 | Methylation | score1 | IEDB | 31844290 | ||
| Y494 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y501 | Phosphorylation | score1 | PhosphoSitePlus |
P51451 (BLK) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P11912 (CD79A) | Y188 | score2 | neXtProt | 7592958 | |
| P11912 (CD79A) | Y199 | score2 | neXtProt | 7592958 | |
| P12318-2 (FCGR2A) | Y280 | score1 | HPRD | 8756631 | |
| P12318 (FCGR2A) | Y281 | score2 | phospho.ELM | 8756631 | |
| P12318-2 (FCGR2A) | Y287 | score1 | HPRD | 8756631 | |
| P12318 (FCGR2A) | Y288 | score3 | neXtProt phospho.ELM PhosphoSitePlus | 8756631 | |
| P12318-2 (FCGR2A) | Y303 | score1 | HPRD | 8756631 | |
| P12318 (FCGR2A) | Y304 | score3 | neXtProt phospho.ELM PhosphoSitePlus | 8756631 | |
| P31994-5 (FCGR2B) | Y272 | score1 | HPRD | 8756631 | |
| P31994-2 (FCGR2B) | Y273 | score1 | HPRD | 8756631 | |
| P31994-4 (FCGR2B) | Y291 | score1 | HPRD | 8756631 | |
| P31994 (FCGR2B) | Y292 | score3 | HPRD neXtProt phospho.ELM PhosphoSitePlus | 8756631 | |
| P31995 (FCGR2C) | Y294 | score2 | neXtProt | 8756631 | |
| P31995 (FCGR2C) | Y310 | score3 | neXtProt PhosphoSitePlus | 8756631 | |
| P40259 (CD79B) | Y196 | score2 | neXtProt | 7592958 | |
| P40259 (CD79B) | Y207 | score2 | neXtProt | 7592958 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y107 | C107 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y188 | * | Biomuta | [ cosmic ] | |
| K325 | T325 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S341 | L341 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] |
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