Protein Information

Cytoscape View


UniProt AC / UniProt ID P51178 / PLCD1_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Gene Name Name: PLCD1
Organism Homo sapiens (Human)

PRO ID PR:P51178
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 that is encoded in the genome of human.
Short Label hPLCD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51178 (PLCD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S501 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T61 I61 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K102 N102 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S195 Y195 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S637 L637 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S650 A650 Biomuta DOID:1909 / melanoma [ cosmic ]
K712 N712 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]