iPTMnet Report for P51116 (FXR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51116 / FXR2_HUMAN
Protein Name RNA-binding protein FXR2
Gene Name Name: FXR2
Synonyms:FMR1L2;
Organism Homo sapiens (Human)

PRO ID PR:P51116
DAG View
PRO Name RNA-binding protein FXR2 (human)
Definition An RNA-binding protein FXR2 that is encoded in the genome of human.
Short Label hFXR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51116 (FXR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD   PhosphoSitePlus 20068231
S21 Phosphorylation PhosphoSitePlus
Y26 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus   UniProt 23186163
K205 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
R393 Methylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
R399 Methylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S410 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T411 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 18669648, 23186163, ...20068231
S414 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S415 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S418 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
R432 Methylation PhosphoSitePlus
R434 Methylation PhosphoSitePlus
R436 Methylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S447 Phosphorylation HPRD   phospho.ELM 18669648
S450 Phosphorylation PhosphoSitePlus
T451 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S453 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 19664994, ...18452278, 18669648
T455 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S457 Phosphorylation PhosphoSitePlus
R476 Methylation PhosphoSitePlus
R488 Methylation PhosphoSitePlus
R490 Methylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
T524 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S525 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S533 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S548 Phosphorylation PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
R557 Methylation PhosphoSitePlus
S566 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18452278
T572 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus   UniProt 23186163
T598 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 18220336, ...18452278, 19651622, 18669648, 24275569, 19690332, 20068231
S601 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 23186163, ...17081983, 18220336, 18767875, 15144186, 18452278, 19651622, 18669648, 19690332, 24275569, 19415658, 20068231
S603 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18220336, 15144186, 18452278, 19651622, 18691976, 18669648, 19415658, 19690332, 20068231
T610 O-Glycosylation GlyGen 23301498, 33214551, 28657654, ...34019948, 28510447, 22121020, 34229054
T610 Phosphorylation HPRD   PhosphoSitePlus 17081983
Y614 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
S639 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T70 K70 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y113 C113 Biomuta DOID:1324 / lung cancer [ cosmic ]
R393 C393 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S397 T397 Biomuta DOID:263 / kidney cancer [ cosmic ]
R399 W399 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T411 I411 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S414 N414 Biomuta DOID:1324 / lung cancer [ cosmic ]
R432 C432 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R436 Q436 Biomuta DOID:3571 / liver cancer [ cosmic ]
S447 L447 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R476 Q476 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S500 L500 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S504 Y504 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S506 Y506 Biomuta DOID:1319 / brain cancer [ icgc ]
S509 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S525 F525 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S533 P533 Biomuta DOID:4159 / skin cancer [ cosmic ]
R557 K557 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S580 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y614 C614 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S639 L639 Biomuta DOID:4159 / skin cancer [ cosmic ]
S654 L654 Biomuta DOID:363 / uterine cancer [ icgc ]