iPTMnet Report for P50993 (ATP1A2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50993 / AT1A2_HUMAN
Protein Name Sodium/potassium-transporting ATPase subunit alpha-2 precursor
Gene Name Name: ATP1A2
Synonyms:KIAA0778;
Organism Homo sapiens (Human)

PRO ID PR:P50993
DAG View
PRO Name sodium/potassium-transporting ATPase subunit alpha-2 (human)
Definition A sodium/potassium-transporting ATPase subunit alpha-2 that is encoded in the genome of human.
Short Label hATP1A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50993 (ATP1A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y9 Phosphorylation PhosphoSitePlus
S153 O-Glycosylation GlyGen 29351928
S215 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
T259 Phosphorylation HPRD   PhosphoSitePlus 20068231
K357 Ubiquitination PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
T570 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S587 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K602 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
T620 Phosphorylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
K840 Acetylation PhosphoSitePlus
K840 Ubiquitination PhosphoSitePlus
R845 Methylation PhosphoSitePlus
T904 Phosphorylation PhosphoSitePlus
Y905 Phosphorylation PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus
K947 Ubiquitination PhosphoSitePlus
K949 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S220 L220 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T376 M376 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S439 F439 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y539 C539 Biomuta DOID:1319 / brain cancer [ cosmic ]
T570 M570 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K602 E602 Biomuta DOID:363 / uterine cancer [ icgc ]
K770 N770 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T904 N904 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y905 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K949 * Biomuta DOID:3571 / liver cancer [ cosmic ]