Protein Information

Cytoscape View

UniProt AC / UniProt ID P50991 / TCPD_HUMAN
Protein Name T-complex protein 1 subunit delta
Gene Name Name: CCT4
Organism Homo sapiens (Human)

PRO ID PR:P50991
DAG View
PRO Name T-complex protein 1 subunit delta (human)
Definition A T-complex protein 1 subunit delta that is encoded in the genome of human.
Short Label hCCT4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P50991 (CCT4) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R8 Methylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
R19 Methylation PhosphoSitePlus   UniProt 24129315
K21 Methylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus   UniProt 23186163
K42 Ubiquitination PhosphoSitePlus
R49 Methylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
K139 Methylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus   UniProt 23186163
T199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus   UniProt 23186163
R206 Methylation PhosphoSitePlus
K209 Sumoylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
T217 O-Glycosylation GlyGen 23301498, 16408927, 30397120, ...26853435, 21740066, 25367160, 32119511
K232 Ubiquitination PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
R274 Methylation PhosphoSitePlus
K288 Acetylation PhosphoSitePlus   UniProt 19608861
K288 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
C295 S-Nitrosylation dbSNO 2212679, 22126794, 22178444, ...26338901, 20140087
K302 Acetylation PhosphoSitePlus   UniProt 19608861
K302 Ubiquitination PhosphoSitePlus
K319 Acetylation PhosphoSitePlus   UniProt 19608861
K319 Ubiquitination PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus   UniProt 19608861
K343 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
C379 S-Nitrosylation dbSNO 19483679, 20140087, 22178444
S381 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K395 Acetylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
C410 S-Nitrosylation dbSNO 19483679
S444 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y449 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
K489 Acetylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S170 Phosphorylation HPRD 19664995
S180 Phosphorylation HPRD 20068231
S181 Phosphorylation HPRD 20068231
S184 Phosphorylation HPRD 20068231
S187 Phosphorylation HPRD 20068231
S381 Phosphorylation HPRD 20068231


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036346 (hCCT4/Ac:1) acM1 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 R9 Biomuta DOID:3571 / liver cancer [ icgc ]
K65 E65 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S180 L180 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T199 A199 Biomuta DOID:4362 / cervical cancer [ tcga ]
K245 T245 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R274 * Biomuta DOID:0070003 / blastoma [ cosmic ]
K302 T302 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K302 N302 Biomuta DOID:1324 / lung cancer [ cosmic ]
S381 G381 Biomuta DOID:3070 / malignant glioma [ tcga ]
K384 R384 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
C410 W410 Biomuta DOID:263 / kidney cancer [ tcga ]
Y449 H449 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]