Protein Information

Cytoscape View


UniProt AC / UniProt ID P50747 / BPL1_HUMAN
Protein Name Biotin--protein ligase
Gene Name Name: HLCS
Organism Homo sapiens (Human)

PRO ID PR:P50747
DAG View
PRO Name biotin--protein ligase (human)
Definition A biotin--protein ligase that is encoded in the genome of human.
Short Label hHLCS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50747 (HLCS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
T146 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S147 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y236 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus   UniProt 23186163
K567 Ubiquitination PhosphoSitePlus
Y635 Phosphorylation PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S81 C81 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S238 F238 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
T642 I642 Biomuta DOID:363 / uterine cancer [ tcga ]