Protein Information

Cytoscape View


UniProt AC / UniProt ID P50613 / CDK7_HUMAN
Protein Name Cyclin-dependent kinase 7
Gene Name Name: CDK7
Synonyms:CAK,CAK1,CDKN7,MO15,STK1;
Organism Homo sapiens (Human)

PRO ID PR:P50613
DAG View
PRO Name cyclin-dependent kinase 7 (human)
Definition A cyclin-dependent kinase 7 that is encoded in the genome of human.
Short Label hCDK7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50613 (CDK7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K6 Ubiquitination PhosphoSitePlus
S7 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
T25 Phosphorylation HPRD 18691976
K32 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S161 Phosphorylation Q9HC98 (NEK6) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 12023960
S164 Phosphorylation P24941 (CDK2) , P50613 (CDK7) , P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 23186163, 9725911, ...17192257, 19651622, 11113184, 18669648, 30651597, 9832506, 20068231
Y169 Phosphorylation HPRD   PhosphoSitePlus 18691976
T170 Phosphorylation P50613 (CDK7) , P41743 (PRKCI) , P06493 (CDK1) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15530371, 17192257, 11113184, ...31784510, 18691976, 21406692, 23186163, 18212344, 27197304, 30651597, 19690332, 18220336, 18767875, 19651622, 9832506, 22021906, 28539972, 28368408, 9725911, 19664995, 18669648, 20166139, 20068231, 23737759
T175 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T287 Phosphorylation HPRD   PhosphoSitePlus 18691976
K291 Ubiquitination PhosphoSitePlus
T316 Phosphorylation HPRD 18691976
K318 Ubiquitination PhosphoSitePlus
S321 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
K328 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus


P50613 (CDK7) as PTM Enzyme



Substrate Site Score Source PMID
P03372 (ESR1) S118 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12118371, 10949034, 15461668
P04637 (TP53) S33 phospho.ELM   PhosphoSitePlus   Signor 9372954
P04637 (TP53) S371 phospho.ELM   PhosphoSitePlus   Signor 9315650
P04637 (TP53) S376 phospho.ELM   PhosphoSitePlus   Signor 9315650
P04637 (TP53) S378 phospho.ELM   PhosphoSitePlus   Signor 9315650
P04637 (TP53) S392 phospho.ELM   PhosphoSitePlus   Signor 9315650
P06493-1 (CDK1) T161 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18691976, 8344251, 22505032, ...21900495, 18767875, 16327805, 19664995, 18452278, 19651622, 12663041, 18669648, 10913154, 16565220, 7944411, 20068231, 17924679
P10275 (AR) S516 PhosphoSitePlus   Signor 21157430
P10276 (RARA) S77 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19078967, 21297158, 9230306, ...12054865, 16769902, 11955452
P11802 (CDK4) T172 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8139570, 19237555, 16327805, ...16782892
P13631 (RARG) S77 neXtProt   PhosphoSitePlus 10748061
P13631 (RARG) S79 neXtProt   PhosphoSitePlus 10748061
P14859 (POU2F1) S385 phospho.ELM 9368058
P21127 (CDK11B) T595 PhosphoSitePlus   Signor 16327805
P24928 (POLR2A) S1616 neXtProt   PhosphoSitePlus 10886368, 19901026, 19667075, ...9130709, 19450536
P24928 (POLR2A) S1619 neXtProt   PhosphoSitePlus   Signor 20106982, 10886368, 14662762, ...14517250, 19901026, 19667075, 9130709, 19450536
P24928 (POLR2A) S1621 neXtProt   PhosphoSitePlus 10886368, 19901026, 19667075, ...9130709, 19450536
P24928 (POLR2A) S1626 Signor 14662762
P24928 (POLR2A) S1647 Signor 14662762
P24928 (POLR2A) S1654 Signor 14662762
P24928 (POLR2A) S1668 Signor 14662762
P24928 (POLR2A) S1675 Signor 14662762
P24928 (POLR2A) S1696 Signor 14662762
P24928 (POLR2A) S1717 Signor 14662762
P24928 (POLR2A) S1724 Signor 14662762
P24928 (POLR2A) S1738 Signor 14662762
P24928 (POLR2A) S1766 Signor 14662762
P24928 (POLR2A) S1787 Signor 14662762
P24928 (POLR2A) S1864 Signor 14662762
P24928 (POLR2A) S1871 Signor 14662762
P24928 (POLR2A) S1878 RLIMS-P+ 27197304
P24928 (POLR2A) S1882 Signor 14662762
P24928 (POLR2A) S1892 Signor 14662762
P24928 (POLR2A) S1899 Signor 14662762
P24928 (POLR2A) S1913 Signor 14662762
P24928 (POLR2A) S1920 Signor 14662762
P24928 (POLR2A) S1927 Signor 14662762
P24928 (POLR2A) S1934 Signor 14662762
P24928 (POLR2A) S1944 Signor 14662762
P24928 (POLR2A) S1951 Signor 14662762
P24941 (CDK2) S46 PhosphoSitePlus 18396144
P24941 (CDK2) T160 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+ 18396144, 16327805, 18767875, ...10085115, 10886368, 17386261, 22505032, 14551212, 11959850, 9244189, 10931829, 8443411, 18452278, 9130709, 9038181, 20068231, 14597612
P24941 (CDK2) T165 PhosphoSitePlus 18396144
P24941 (CDK2) Y168 PhosphoSitePlus 18396144
P37231 (PPARG) S112 neXtProt 18981214, 15988019
P49736 (MCM2) S4 PhosphoSitePlus 16864800
P49736 (MCM2) S5 PhosphoSitePlus 16864800
P49736 (MCM2) S7 PhosphoSitePlus 16864800
P49736 (MCM2) S13 PhosphoSitePlus 16446360
P49736 (MCM2) S27 PhosphoSitePlus   Signor 16446360, 16899510
P49736 (MCM2) S40 PhosphoSitePlus 16446360
P49736 (MCM2) S41 PhosphoSitePlus   Signor 16446360, 16899510
P49736 (MCM2) S53 PhosphoSitePlus 16446360, 16864800
P49736 (MCM2) T59 PhosphoSitePlus 16864800
P49736 (MCM2) S108 PhosphoSitePlus 16446360
P49736 (MCM2) S139 PhosphoSitePlus   Signor 16446360, 16899510
P50613 (CDK7) S164 phospho.ELM 11113184
P50613 (CDK7) T170 phospho.ELM 11113184
Q00534 (CDK6) T177 PhosphoSitePlus 16782892
Q01094 (E2F1) S403 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10428966
Q01094 (E2F1) T433 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10428966
Q01860 (POU5F1) S12 Signor 31306665
Q13285 (NR5A1) S203 neXtProt   PhosphoSitePlus   Signor 17901130
Q14847-1 (LASP1) S146 HPRD   phospho.ELM 17287340, 18212344, 12571245, ...18077418, 18669648, 20166139, 18088087, 20068231
Q15797 (SMAD1) S206 PhosphoSitePlus 19914168
Q9BYE7 (PCGF6) S30 HPRD   neXtProt   PhosphoSitePlus 12167161
Q9H0D6 (XRN2) T439 PhosphoSitePlus   Signor 26728557
Q9NYV4 (CDK12) T893 PhosphoSitePlus 24662513
Q9UPZ9 (CILK1) T157 neXtProt   phospho.ELM 15988018


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P50613 (CDK7) S164 P51946 (CCNH) increased_association eFIP 32385714


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 Y7 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T25 S25 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
K41 N41 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:1612 / breast cancer [ cosmic, icgc ]
S161 Y161 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T175 I175 Biomuta DOID:4159 / skin cancer [ icgc ]
T316 A316 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]