iPTMnet Report P50613 CDK7

Protein Information

UniProt AC / UniProt ID	P50613 / CDK7_HUMAN
Protein Name	Cyclin-dependent kinase 7
Gene Name	Name: CDK7 Synonyms:CAK,CAK1,CDKN7,MO15,STK1;
Organism	Homo sapiens (Human)

PRO ID	PR:P50613 DAG View
PRO Name	cyclin-dependent kinase 7 (human)
Definition	A cyclin-dependent kinase 7 that is encoded in the genome of human.
Short Label	hCDK7
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P50613 (CDK7) as Substrate

P50613

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position A2 K6 S7 T25 K32 K41 S106 T110 K139 K160 S161 S164 Y169 T170 T175 S217 T287 K291 T316 K318 S321 K328 K330 T332	PTM Type Select all Acetylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 4	Source Select all HPRD IEDB PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
A2	Acetylation		score1	UniProt	22814378
K6	Ubiquitination		score1	PhosphoSitePlus
S7	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	18691976, 20068231
T25	Phosphorylation		score0	HPRD	18691976
K32	Ubiquitination		score1	PhosphoSitePlus
K41	Ubiquitination		score1	PhosphoSitePlus
S106	Phosphorylation		score1	PhosphoSitePlus
T110	Phosphorylation		score1	PhosphoSitePlus
K139	Ubiquitination		score1	PhosphoSitePlus
K160	Ubiquitination		score1	PhosphoSitePlus
S161	Phosphorylation	Q9HC98 (NEK6)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	18691976, 18669648, 12023960
S164	Phosphorylation	P24941 (CDK2) , P50613 (CDK7) , P06493 (CDK1)	score4	HPRD IEDB neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18691976, 23186163, 29437277, ...9725911, 17192257, 19651622, 11113184, 18669648, 35337817, 30651597, 32157095, 9832506, 20068231
Y169	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
T170	Phosphorylation	P50613 (CDK7) , P41743 (PRKCI) , P06493 (CDK1) , P24941 (CDK2)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15530371, 17192257, 9832506, ...31784510, 18691976, 21406692, 23186163, 18212344, 35337817, 30651597, 19690332, 18220336, 18767875, 19651622, 11113184, 22021906, 28539972, 28368408, 9725911, 19664995, 18669648, 20166139, 20068231, 23737759
T175	Phosphorylation		score1	PhosphoSitePlus
S217	Phosphorylation		score1	PhosphoSitePlus
T287	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
K291	Ubiquitination		score1	PhosphoSitePlus
T316	Phosphorylation		score0	HPRD	18691976
K318	Ubiquitination		score1	PhosphoSitePlus
S321	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	18691976, 20068231
K328	Ubiquitination		score1	PhosphoSitePlus
K330	Ubiquitination		score1	PhosphoSitePlus
T332	Phosphorylation		score1	PhosphoSitePlus

P50613 (CDK7) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P03372-1 (ESR1) P04637 (TP53) P06493 (CDK1) P10275 (AR) P10276 (RARA) P11802 (CDK4) P13631 (RARG) P14859 (POU2F1) P21127 (CDK11B) P24928 (POLR2A) P24941 (CDK2) P24941-1 (CDK2) P37231 (PPARG) P49736 (MCM2) P50613 (CDK7) Q00534 (CDK6) Q01094 (E2F1) Q01860 (POU5F1) Q13285 (NR5A1) Q14847 (LASP1) Q15797 (SMAD1) Q9BYE7-1 (PCGF6) Q9H0D6 (XRN2) Q9NYV4 (CDK12) Q9UPZ9 (CILK1)	Site Select all By amino acid All Serine All Threonine All Tyrosine By position S4 S5 S7 S12 S13 S27 S30 S33 S40 S41 S46 S53 T59 S77 S79 S108 S112 S118 S139 S146 T157 T160 T161 S164 T165 Y168 T170 T172 T177 S203 S206 S371 S376 S378 S385 S392 S403 T433 T439 S516 T595 T893 S1616 S1619 S1621 S1626 S1647 S1654 S1668 S1675 S1696 S1717 S1724 S1738 S1766 S1787 S1864 S1871 S1878 S1882 S1892 S1899 S1913 S1920 S1927 S1934 S1944 S1951	Score Select all 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P+ Signor neXtProt phospho.ELM	PMID
P03372-1 (ESR1)	S118	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	12118371, 10949034, 15461668
P04637 (TP53)	S33	score3	phospho.ELM PhosphoSitePlus Signor	9372954
P04637 (TP53)	S371	score3	phospho.ELM PhosphoSitePlus Signor	9315650
P04637 (TP53)	S376	score3	phospho.ELM PhosphoSitePlus Signor	9315650
P04637 (TP53)	S378	score3	phospho.ELM PhosphoSitePlus Signor	9315650
P04637 (TP53)	S392	score3	phospho.ELM PhosphoSitePlus Signor	9315650
P06493 (CDK1)	T161	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	7944411, 18691976, 16327805, ...16565220, 21900495, 8344251, 18767875, 19664995, 22505032, 19651622, 18669648, 20068231, 18452278, 12663041, 10913154, 17924679
P10275 (AR)	S516	score3	PhosphoSitePlus Signor	21157430
P10276 (RARA)	S77	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	19078967, 21297158, 9230306, ...12054865, 16769902, 11955452
P11802 (CDK4)	T172	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	8139570, 19237555, 16327805, ...16782892
P13631 (RARG)	S77	score3	neXtProt PhosphoSitePlus	10748061
P13631 (RARG)	S79	score3	neXtProt PhosphoSitePlus	10748061
P14859 (POU2F1)	S385	score2	phospho.ELM	9368058
P21127 (CDK11B)	T595	score3	PhosphoSitePlus Signor	16327805
P24928 (POLR2A)	S1616	score4	neXtProt PhosphoSitePlus	10886368, 19901026, 19667075, ...9130709, 19450536
P24928 (POLR2A)	S1619	score4	neXtProt PhosphoSitePlus Signor	20106982, 10886368, 14662762, ...14517250, 19901026, 19667075, 9130709, 19450536
P24928 (POLR2A)	S1621	score4	neXtProt PhosphoSitePlus	10886368, 19901026, 19667075, ...9130709, 19450536
P24928 (POLR2A)	S1626	score1	Signor	14662762
P24928 (POLR2A)	S1647	score1	Signor	14662762
P24928 (POLR2A)	S1654	score1	Signor	14662762
P24928 (POLR2A)	S1668	score1	Signor	14662762
P24928 (POLR2A)	S1675	score1	Signor	14662762
P24928 (POLR2A)	S1696	score1	Signor	14662762
P24928 (POLR2A)	S1717	score1	Signor	14662762
P24928 (POLR2A)	S1724	score1	Signor	14662762
P24928 (POLR2A)	S1738	score1	Signor	14662762
P24928 (POLR2A)	S1766	score1	Signor	14662762
P24928 (POLR2A)	S1787	score1	Signor	14662762
P24928 (POLR2A)	S1864	score1	Signor	14662762
P24928 (POLR2A)	S1871	score1	Signor	14662762
P24928 (POLR2A)	S1878	score2	RLIMS-P+	27197304
P24928 (POLR2A)	S1882	score1	Signor	14662762
P24928 (POLR2A)	S1892	score1	Signor	14662762
P24928 (POLR2A)	S1899	score1	Signor	14662762
P24928 (POLR2A)	S1913	score1	Signor	14662762
P24928 (POLR2A)	S1920	score1	Signor	14662762
P24928 (POLR2A)	S1927	score1	Signor	14662762
P24928 (POLR2A)	S1934	score1	Signor	14662762
P24928 (POLR2A)	S1944	score1	Signor	14662762
P24928 (POLR2A)	S1951	score1	Signor	14662762
P24941 (CDK2)	S46	score2	PhosphoSitePlus	18396144
P24941-1 (CDK2)	T160	score4	HPRD neXtProt PhosphoSitePlus RLIMS-P+	18396144, 16327805, 18767875, ...10085115, 10886368, 17386261, 18452278, 14551212, 8443411, 10931829, 9244189, 11959850, 22505032, 9130709, 9038181, 20068231, 14597612
P24941 (CDK2)	T165	score2	PhosphoSitePlus	18396144
P24941 (CDK2)	Y168	score2	PhosphoSitePlus	18396144
P37231 (PPARG)	S112	score3	neXtProt	18981214, 15988019
P49736 (MCM2)	S4	score2	PhosphoSitePlus	16864800
P49736 (MCM2)	S5	score2	PhosphoSitePlus	16864800
P49736 (MCM2)	S7	score2	PhosphoSitePlus	16864800
P49736 (MCM2)	S13	score2	PhosphoSitePlus	16446360
P49736 (MCM2)	S27	score4	PhosphoSitePlus Signor	16446360, 16899510
P49736 (MCM2)	S40	score2	PhosphoSitePlus	16446360
P49736 (MCM2)	S41	score4	PhosphoSitePlus Signor	16446360, 16899510
P49736 (MCM2)	S53	score3	PhosphoSitePlus	16446360, 16864800
P49736 (MCM2)	T59	score2	PhosphoSitePlus	16864800
P49736 (MCM2)	S108	score2	PhosphoSitePlus	16446360
P49736 (MCM2)	S139	score4	PhosphoSitePlus Signor	16446360, 16899510
P50613 (CDK7)	S164	score2	phospho.ELM	11113184
P50613 (CDK7)	T170	score2	phospho.ELM	11113184
Q00534 (CDK6)	T177	score2	PhosphoSitePlus	16782892
Q01094 (E2F1)	S403	score3	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	10428966
Q01094 (E2F1)	T433	score3	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	10428966
Q01860 (POU5F1)	S12	score1	Signor	31306665
Q13285 (NR5A1)	S203	score3	neXtProt PhosphoSitePlus Signor	17901130
Q14847 (LASP1)	S146	score4	HPRD phospho.ELM	17287340, 18212344, 12571245, ...18077418, 18669648, 20166139, 18088087, 20068231
Q15797 (SMAD1)	S206	score2	PhosphoSitePlus	19914168
Q9BYE7-1 (PCGF6)	S30	score3	HPRD neXtProt PhosphoSitePlus	12167161
Q9H0D6 (XRN2)	T439	score3	PhosphoSitePlus Signor	26728557
Q9NYV4 (CDK12)	T893	score2	PhosphoSitePlus	24662513
Q9UPZ9 (CILK1)	T157	score3	neXtProt phospho.ELM	15988018

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P50613 (CDK7)	Site Select all By amino acid All Serine By position S164	Interactant Select all P51946 (CCNH)	Association type Select all increased_association	Source Select all eFIP	PMID
	Phosphorylation	P50613 (CDK7)	S164	P51946 (CCNH)	increased_association	eFIP	32385714

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P50613 (CDK7)

Protein Information

Interactive Sequence View

P50613 (CDK7) as Substrate

P50613 (CDK7) as PTM Enzyme

PTM-dependent PPI