iPTMnet Report for P50579 (METAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50579 / MAP2_HUMAN
Protein Name Methionine aminopeptidase 2
Gene Name Name: METAP2
Synonyms:MNPEP,P67EIF2;
Organism Homo sapiens (Human)

PRO ID PR:P50579
DAG View
PRO Name methionine aminopeptidase 2 (human)
Definition A methionine aminopeptidase 2 that is encoded in the genome of human.
Short Label hMETAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50579 (METAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
R23 Methylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
S45 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S49 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S60 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S63 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S74 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K79 Ubiquitination PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
S185 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35254053
C197 Methylation IEDB 31844290
C223 Methylation IEDB 31844290
C263 Methylation IEDB 31844290
K278 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
C380 Methylation IEDB 31844290
K385 Ubiquitination PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
C436 S-Nitrosylation dbSNO 19483679
C448 S-Nitrosylation dbSNO 19483679
Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation HPRD 18669648, 20068231
S60 Phosphorylation HPRD 18669648
S63 Phosphorylation HPRD 18669648
S74 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K57 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K57 T57 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K58 T58 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K98 N98 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T145 A145 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T145 R145 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C223 Y223 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K289 Q289 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K323 * Biomuta DOID:1612 / breast cancer [ cosmic ]
C448 W448 Biomuta DOID:4159 / skin cancer [ cosmic ]