iPTMnet Report for P50570 (DNM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50570 / DYN2_HUMAN
Protein Name Dynamin-2
Gene Name Name: DNM2
Synonyms:DYN2;
Organism Homo sapiens (Human)

PRO ID PR:P50570
DAG View
PRO Name dynamin-2 (human)
Definition A dynamin-2 that is encoded in the genome of human.
Short Label hDNM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50570 (DNM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation IEDB 32387766
C27 S-Nitrosylation dbSNO 22178444, 17251380
S46 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
C86 S-Nitrosylation dbSNO 2212679, 22126794, 22178444, ...17251380
K87 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K299 Acetylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
T456 Phosphorylation PhosphoSitePlus
Y463 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K562 Acetylation PhosphoSitePlus
Y563 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
K598 Acetylation PhosphoSitePlus   UniProt 19608861
K598 Ubiquitination PhosphoSitePlus
C607 S-Nitrosylation dbSNO 22178444, 17251380
K617 Ubiquitination PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
Y663 Phosphorylation PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
Y726 Phosphorylation PhosphoSitePlus
T755 Phosphorylation PhosphoSitePlus   UniProt 24275569
S759 Phosphorylation PhosphoSitePlus
S761 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S762 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S764 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 20889493, 18669648, 21195118
T766 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus 20889493, 18669648
R785 Methylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus   RLIMS-P 12205083
R850 Methylation PhosphoSitePlus
R857 Methylation PhosphoSitePlus
R862 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T200 Phosphorylation HPRD 18452278
Y449 Phosphorylation HPRD 18691976
S532 Phosphorylation HPRD 20068231
Y563 Phosphorylation HPRD 20068231
S581 Phosphorylation HPRD 20068231
T591 Phosphorylation HPRD 20068231
S619 Phosphorylation HPRD 18767875
S662 Phosphorylation HPRD 20068231
T755 Phosphorylation HPRD 18452278
S759 Phosphorylation HPRD 18452278
S761 Phosphorylation HPRD 18669648, 20068231
S762 Phosphorylation HPRD 18669648, 18452278
S764 Phosphorylation HPRD 18669648, 20068231, 18452278
T766 Phosphorylation HPRD 18669648, 15302935, 18452278
Site PTM Type PTM Enzyme Score Source PMID
T200 Phosphorylation HPRD 18452278
Y449 Phosphorylation HPRD 18691976
S528 Phosphorylation HPRD 20068231
Y559 Phosphorylation HPRD 20068231
S577 Phosphorylation HPRD 20068231
T587 Phosphorylation HPRD 20068231
S615 Phosphorylation HPRD 18767875
S658 Phosphorylation HPRD 20068231
T751 Phosphorylation HPRD 18452278
S755 Phosphorylation HPRD 18452278
S757 Phosphorylation HPRD 18669648, 20068231
S758 Phosphorylation HPRD 18669648, 18452278
S760 Phosphorylation HPRD 18669648, 20068231, 18452278
T762 Phosphorylation HPRD 18669648, 15302935, 18452278
Site PTM Type PTM Enzyme Score Source PMID
T200 Phosphorylation HPRD 18452278
S528 Phosphorylation HPRD 20068231
Y559 Phosphorylation HPRD 20068231
S577 Phosphorylation HPRD 20068231
T587 Phosphorylation HPRD 20068231
S615 Phosphorylation HPRD 18767875
S658 Phosphorylation HPRD 20068231
T751 Phosphorylation HPRD 18452278
S755 Phosphorylation HPRD 18452278
S757 Phosphorylation HPRD 18669648, 20068231
S758 Phosphorylation HPRD 18669648, 18452278
S760 Phosphorylation HPRD 18669648, 20068231, 18452278
T762 Phosphorylation HPRD 18669648, 15302935, 18452278
Site PTM Type PTM Enzyme Score Source PMID
T200 Phosphorylation HPRD 18452278
S532 Phosphorylation HPRD 20068231
Y563 Phosphorylation HPRD 20068231
S581 Phosphorylation HPRD 20068231
T591 Phosphorylation HPRD 20068231
S619 Phosphorylation HPRD 18767875
S662 Phosphorylation HPRD 20068231
T755 Phosphorylation HPRD 18452278
S759 Phosphorylation HPRD 18452278
S761 Phosphorylation HPRD 18669648, 20068231
S762 Phosphorylation HPRD 18669648, 18452278
S764 Phosphorylation HPRD 18669648, 20068231, 18452278
T766 Phosphorylation HPRD 18669648, 15302935, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 L61 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C86 S86 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
T214 I214 Biomuta [ cosmic ]
K257 T257 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T280 K280 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T280 M280 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K315 N315 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S357 F357 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K376 M376 Biomuta DOID:3277 / thymus cancer [ cosmic ]
K382 E382 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y449 C449 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T456 I456 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T527 I527 Biomuta DOID:4159 / skin cancer [ cosmic ]
S528 I528 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S532 I532 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S577 F577 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S581 F581 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T587 A587 Biomuta DOID:4159 / skin cancer [ cosmic ]
T591 A591 Biomuta DOID:4159 / skin cancer [ cosmic ]
S615 L615 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S619 L619 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
Y663 D663 Biomuta DOID:4159 / skin cancer [ cosmic ]
S755 I755 Biomuta DOID:363 / uterine cancer [ icgc ]
S759 I759 Biomuta DOID:363 / uterine cancer [ icgc ]
T762 P762 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, cosmic, icgc, cosmic, cosmic, cosmic, icgc, cosmic ] DOID:363 / uterine cancer [ icgc, icgc ] DOID:2531 / hematologic cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, cosmic, icgc ]
T766 P766 Biomuta DOID:4159 / skin cancer [ cosmic ]
R857 W857 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R857 Q857 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R862 L862 Biomuta [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]