iPTMnet Report P50548 ERF

Protein Information

UniProt AC / UniProt ID	P50548 / ERF_HUMAN
Protein Name	ETS domain-containing transcription factor ERF
Gene Name	Name: ERF
Organism	Homo sapiens (Human)

PRO ID	PR:P50548 DAG View
PRO Name	ETS domain-containing transcription factor ERF (human)
Definition	An ETS domain-containing transcription factor ERF that is encoded in the genome of human.
Short Label	hERF
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P50548 (ERF) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K2	Methylation		score1	PhosphoSitePlus
K2	Ubiquitination		score1	PhosphoSitePlus
T3	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
T7	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
Y16	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
K17	Ubiquitination		score1	PhosphoSitePlus
S20	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
S21	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S24	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K71	Ubiquitination		score1	PhosphoSitePlus
K73	Ubiquitination		score1	PhosphoSitePlus
K80	Ubiquitination		score1	PhosphoSitePlus
K105	Ubiquitination		score1	PhosphoSitePlus
S131	Phosphorylation		score1	PhosphoSitePlus
S147	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T148	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S150	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S154	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T156	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S161	Phosphorylation	P28482 (MAPK1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	10330152, 18669648
S166	Phosphorylation		score1	PhosphoSitePlus
S167	Phosphorylation		score1	PhosphoSitePlus
S169	Phosphorylation		score1	PhosphoSitePlus
S170	Phosphorylation		score1	PhosphoSitePlus
S171	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
R183	Methylation		score1	PhosphoSitePlus
S185	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S187	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S190	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 17081983
R218	Methylation		score1	PhosphoSitePlus
R224	Methylation		score1	PhosphoSitePlus
R233	Methylation		score1	PhosphoSitePlus
S246	Phosphorylation	P28482 (MAPK1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	10330152, 14729966
S251	Phosphorylation	P28482 (MAPK1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	10330152, 14729966
S327	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
R329	Methylation		score1	PhosphoSitePlus
T357	Phosphorylation		score1	PhosphoSitePlus
S367	Phosphorylation		score1	PhosphoSitePlus
S368	Phosphorylation		score1	PhosphoSitePlus
S369	Phosphorylation		score1	PhosphoSitePlus
S370	Phosphorylation		score1	PhosphoSitePlus
K376	Methylation		score1	PhosphoSitePlus
K378	Sumoylation		score1	PhosphoSitePlus
K394	Acetylation		score1	PhosphoSitePlus
S431	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 19690332
S435	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
T441	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
S444	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 19690332
T456	Phosphorylation		score1	PhosphoSitePlus
K465	Sumoylation		score1	PhosphoSitePlus
S489	Phosphorylation		score1	PhosphoSitePlus
K512	Sumoylation		score1	PhosphoSitePlus
T526	Phosphorylation	P28482 (MAPK1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus Signor UniProt	14729966, 22028470, 23186163, ...16964243, 7588608, 10330152, 18669648, 24275569, 19690332
S531	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 17081983
S532	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S542	Phosphorylation		score1	PhosphoSitePlus
S548	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T3	Phosphorylation		score0	HPRD	18669648
T7	Phosphorylation		score0	HPRD	18669648
Y16	Phosphorylation		score0	HPRD	18669648
S20	Phosphorylation		score0	HPRD	18669648
S21	Phosphorylation		score0	HPRD	18669648, 17081983, 18707149
S147	Phosphorylation		score0	HPRD	18669648
T148	Phosphorylation		score0	HPRD	18669648
S150	Phosphorylation		score0	HPRD	18669648
S154	Phosphorylation		score0	HPRD	18669648
T156	Phosphorylation		score0	HPRD	18669648
S161	Phosphorylation	P28482 (MAPK1)	score2	HPRD	10330152, 18669648
S171	Phosphorylation		score0	HPRD	18669648
S185	Phosphorylation		score0	HPRD	18669648, 17081983
S187	Phosphorylation		score0	HPRD	18669648, 17081983
S190	Phosphorylation		score0	HPRD	18669648, 17081983
S246	Phosphorylation	P28482 (MAPK1)	score1	HPRD	10330152
S251	Phosphorylation	P28482 (MAPK1)	score1	HPRD	10330152
S327	Phosphorylation		score0	HPRD	18669648
S431	Phosphorylation		score0	HPRD	18669648
S435	Phosphorylation		score0	HPRD	18669648
T441	Phosphorylation		score0	HPRD	18669648
S444	Phosphorylation		score0	HPRD	18669648
S489	Phosphorylation		score0	HPRD	18212344
T526	Phosphorylation	P28482 (MAPK1)	score2	HPRD	10330152, 18669648, 19664994, ...18212344
S531	Phosphorylation		score0	HPRD	18767875, 18669648, 17081983
S548	Phosphorylation		score0	HPRD	18669648

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000047326 (hERF/Phos:1)	pT526		PRO

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K2	E2	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S20	L20	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S24	*	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S131	G131	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
T148	M148	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S169	L169	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
R224	L224	Biomuta	DOID:1324 / lung cancer [ cosmic ]
R224	C224	Biomuta	DOID:3277 / thymus cancer [ cosmic ]
R233	P233	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R329	H329	Biomuta	DOID:1793 / pancreatic cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R329	C329	Biomuta	DOID:1324 / lung cancer [ cosmic ]
R329	S329	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T357	N357	Biomuta	DOID:263 / kidney cancer [ cosmic ]
S367	F367	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S368	F368	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K378	R378	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S542	Y542	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S542	A542	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P50548 (ERF)

Protein Information

Interactive Sequence View

P50548 (ERF) as Substrate

Proteoforms

PTM sites affected in variants