iPTMnet Report for P50542 (PEX5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50542 / PEX5_HUMAN
Protein Name Peroxisomal targeting signal 1 receptor
Gene Name Name: PEX5
Synonyms:PXR1;
Organism Homo sapiens (Human)

PRO ID PR:P50542
DAG View
PRO Name peroxisomal targeting signal 1 receptor (human)
Definition A peroxisomal targeting signal 1 receptor that is encoded in the genome of human.
Short Label hPEX5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50542 (PEX5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Ubiquitination PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus   UniProt 24275569
S141 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 26344566, 27050462
S141 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 26344566
T149 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus   UniProt 24275569
S155 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y163 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y185 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus   UniProt 26344566
K217 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S283 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K472 Ubiquitination UniProt 28724525
K527 Ubiquitination PhosphoSitePlus   UniProt 24662292
T633 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K209 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S279 Phosphorylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
T622 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K52 E52 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K83 N83 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y185 F185 Biomuta DOID:1324 / lung cancer [ cosmic ]
K204 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S228 F228 Biomuta DOID:1324 / lung cancer [ cosmic ]
K290 T290 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y312 N312 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K322 T322 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T622 I622 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]