iPTMnet Report for P50416 (CPT1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50416 / CPT1A_HUMAN
Protein Name Carnitine O-palmitoyltransferase 1, liver isoform
Gene Name Name: CPT1A
Synonyms:CPT1;
Organism Homo sapiens (Human)

PRO ID PR:P50416
DAG View
PRO Name carnitine O-palmitoyltransferase 1, liver isoform (human)
Definition A carnitine O-palmitoyltransferase 1, liver isoform that is encoded in the genome of human.
Short Label hCPT1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50416 (CPT1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K86 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
T169 O-Glycosylation GlyGen 33465208
S170 O-Glycosylation GlyGen 28510447, 35083852, 33465208
K180 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S315 O-Glycosylation GlyGen 28510447, 35083852, 33465208
T322 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K86 N86 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S170 L170 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K200 E200 Biomuta DOID:3571 / liver cancer [ cosmic ]
S371 L371 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y514 C514 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K772 R772 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]