Protein Information

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UniProt AC / UniProt ID P50402 / EMD_HUMAN
Protein Name Emerin
Gene Name Name: EMD
Synonyms:EDMD,STA;
Organism Homo sapiens (Human)

PRO ID PR:P50402
DAG View
PRO Name emerin (human)
Definition An emerin that is encoded in the genome of human.
Short Label hEMD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50402 (EMD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 19369195, 21406692, ...22223895, 22814378, 20068231, 25944712
Y4 Phosphorylation HPRD   PhosphoSitePlus 18491316
S8 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...20068231
T10 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
Y19 Phosphorylation P00519 (ABL1) , P12931 (SRC) PhosphoSitePlus 19789182
S29 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 24275569, ...20068231
Y34 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
Y41 Phosphorylation P00519 (ABL1) , P12931 (SRC) phospho.ELM   PhosphoSitePlus 19789182, 16212419
T43 Phosphorylation PhosphoSitePlus
S49 O-Glycosylation GlyGen 32119511, 29351928, 30059200, ...29237092, 24014020
S49 Phosphorylation P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 17081983, ...18220336, 16204256, 18669648, 16972941, 20068231
S52 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S53 O-Glycosylation GlyGen   PhosphoSitePlus 30059200, 29351928, 32119511, ...24014020, 29237092
S53 Phosphorylation PhosphoSitePlus
S54 O-Glycosylation GlyGen   PhosphoSitePlus 30059200, 29351928, 32119511, ...24014020, 29237092
S54 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231, ...18220336
S57 O-Glycosylation GlyGen 32119511, 29351928, 30059200, ...29237092, 24014020
S57 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S58 O-Glycosylation GlyGen 32119511, 29351928, 30059200, ...29237092, 24014020
S58 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
Y59 Phosphorylation P12931 (SRC) , P00519 (ABL1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18669648, 19789182, 16212419, ...18220336
S60 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 20166139, 19690332
S62 O-Glycosylation GlyGen 32119511, 29351928, 30059200, ...29237092, 24014020
S62 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
S66 O-Glycosylation GlyGen 32119511, 29351928, 30059200, ...29237092, 24014020
S66 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 16204256
T67 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 16204256, 17081983
Y74 Phosphorylation P00519 (ABL1) , P12931 (SRC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 29684168, 31185657, 19789182, ...16212419, 20068231
K78 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
Y85 Phosphorylation P00519 (ABL1) , P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus 15592455, 19789182, 16212419
S87 O-Glycosylation GlyGen   PhosphoSitePlus 30059200, 29351928, 32119511, ...24014020, 29237092
S87 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19691289, ...20068231
K88 Ubiquitination PhosphoSitePlus
Y90 Phosphorylation P00519 (ABL1) , P12931 (SRC) HPRD   PhosphoSitePlus 15592455, 19789182
Y94 Phosphorylation P12931 (SRC) , P00519 (ABL1) HPRD   PhosphoSitePlus 15592455, 19789182
Y95 Phosphorylation P12931 (SRC) , P00519 (ABL1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15592455, 19789182, 29684168, ...31185657
S98 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y99 Phosphorylation P12931 (SRC) , P00519 (ABL1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 15592455, 19789182, 29684168
T101 Phosphorylation PhosphoSitePlus
R103 Methylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation P12931 (SRC) , P00519 (ABL1) HPRD   phospho.ELM   PhosphoSitePlus 19789182, 16094384
S110 Phosphorylation HPRD   PhosphoSitePlus 19691289
S120 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 16204256, 17081983, ...20068231
T122 Phosphorylation HPRD 18691976, 17081983, 20068231
S123 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S141 Phosphorylation HPRD   PhosphoSitePlus 17081983
S142 Phosphorylation HPRD   PhosphoSitePlus 18691976, 17081983, 20068231
S143 Phosphorylation HPRD   PhosphoSitePlus 17081983
Y155 Phosphorylation P00519 (ABL1) PhosphoSitePlus 19789182
S159 Phosphorylation HPRD   PhosphoSitePlus 17081983
Y161 Phosphorylation P00519 (ABL1) , P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus 18691976, 19789182, 16212419, ...18707149, 20068231
S163 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 15144186
T165 Phosphorylation HPRD   PhosphoSitePlus 17081983
Y167 Phosphorylation P00519 (ABL1) , P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus 17081983, 19789182, 15144186, ...16212419, 18707149, 20068231
S171 O-Glycosylation GlyGen   PhosphoSitePlus 30059200, 29351928, 32119511, ...24014020, 29237092
S171 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...20230923, 18220336, 19651622, 18669648, 20068231
S173 O-Glycosylation GlyGen   PhosphoSitePlus 30059200, 29351928, 32119511, ...24014020, 29237092
S173 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20230923, ...19651622, 20068231
S175 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 16204256
S176 Phosphorylation PhosphoSitePlus
S180 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y181 Phosphorylation P12931 (SRC) PhosphoSitePlus 19789182
Y182 Phosphorylation P12931 (SRC) PhosphoSitePlus 19789182
S189 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75531 (BANF1) S4 P50402 (EMD) unknown eFIP 16371512


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 L53 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S58 C58 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S66 L66 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K78 M78 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S87 I87 Biomuta DOID:363 / uterine cancer [ tcga ]
Y94 * Biomuta DOID:1909 / melanoma [ cosmic ]
Y181 N181 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S189 P189 Biomuta DOID:363 / uterine cancer [ tcga ]