iPTMnet Report for P50148 (GNAQ)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P50148 / GNAQ_HUMAN
Protein Name Guanine nucleotide-binding protein G(q) subunit alpha
Gene Name Name: GNAQ
Synonyms:GAQ;
Organism Homo sapiens (Human)

PRO ID PR:P50148
DAG View
PRO Name guanine nucleotide-binding protein G(q) subunit alpha (human)
Definition A guanine nucleotide-binding protein G(q) subunit alpha that is encoded in the genome of human.
Short Label hGNAQ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50148 (GNAQ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49789 (FHIT) Y114 P50148 (GNAQ) unknown eFIP 23947369


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S68 F68 Biomuta DOID:4159 / skin cancer [ cosmic ]
K72 E72 Biomuta DOID:1324 / lung cancer [ cosmic ]
K102 N102 Biomuta DOID:3571 / liver cancer [ cosmic ]
K120 N120 Biomuta DOID:1324 / lung cancer [ cosmic ]
T187 I187 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K345 N345 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K354 N354 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]