Protein Information

Cytoscape View


UniProt AC / UniProt ID P49959 / MRE11_HUMAN
Protein Name Double-strand break repair protein MRE11
Gene Name Name: MRE11
Synonyms:HNGS1,MRE11A;
Organism Homo sapiens (Human)

PRO ID PR:P49959
DAG View
PRO Name double-strand break repair protein MRE11 (human)
Definition A double-strand break repair protein MRE11 that is encoded in the genome of human.
Short Label hMRE11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49959 (MRE11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
T12 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
T74 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S158 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
S264 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10608806
T272 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus   UniProt 23186163
K282 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S382 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus 10608806
K384 Ubiquitination PhosphoSitePlus
R388 Methylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K416 Acetylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K480 Acetylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
S531 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus 10608806
S558 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 28436950
S561 Phosphorylation PhosphoSitePlus   RLIMS-P 28436950
R570 Methylation PhosphoSitePlus
R572 Methylation PhosphoSitePlus
R574 Methylation PhosphoSitePlus
R576 Methylation PhosphoSitePlus
R577 Methylation PhosphoSitePlus
R580 Methylation PhosphoSitePlus
R587 Methylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
R592 Methylation PhosphoSitePlus
R594 Methylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus   RLIMS-P 28967905
R604 Methylation PhosphoSitePlus
K609 Acetylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
R616 Methylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus   UniProt 23186163
K625 Sumoylation PhosphoSitePlus
S649 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28512243, 18669648, 24275569, ...15845385, 19690332
S667 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
S676 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P 31353207, 24297933, 26240375
S678 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 31353207, 17525332, 23186163, ...26240375
S681 Phosphorylation PhosphoSitePlus
S688 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 23186163, ...17081983, 15302935, 18669648, 28436950, 24275569, 19690332, 20068231
S689 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 23186163, ...17081983, 15302935, 18669648, 28436950, 24275569, 19690332, 20068231
S701 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S702 Phosphorylation phospho.ELM 18669648
Site PTM Type PTM Enzyme Score Source PMID
T74 Phosphorylation HPRD 15302935
S264 Phosphorylation Q13315 (ATM) HPRD 10608806
S558 Phosphorylation HPRD 18669648, 18452278
T597 Phosphorylation HPRD 18212344
S602 Phosphorylation HPRD 17081983
T603 Phosphorylation HPRD 17081983
S619 Phosphorylation HPRD 18212344
S649 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T662 Phosphorylation HPRD 20068231
S667 Phosphorylation HPRD 20068231
S668 Phosphorylation HPRD 20068231
T669 Phosphorylation HPRD 20068231
S670 Phosphorylation HPRD 20068231
S671 Phosphorylation HPRD 20068231
S676 Phosphorylation HPRD 18077418
S678 Phosphorylation HPRD 17525332, 18077418
S681 Phosphorylation HPRD 20068231
S688 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S689 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 19415658, 20068231
S701 Phosphorylation HPRD 18669648
S702 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T74 Phosphorylation HPRD 15302935
S264 Phosphorylation Q13315 (ATM) HPRD 10608806
S558 Phosphorylation HPRD 18669648, 18452278
K597 Acetylation PhosphoSitePlus
S621 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T634 Phosphorylation HPRD 20068231
S639 Phosphorylation HPRD 20068231
S640 Phosphorylation HPRD 20068231
T641 Phosphorylation HPRD 20068231
S642 Phosphorylation HPRD 20068231
S643 Phosphorylation HPRD 20068231
S648 Phosphorylation HPRD 18077418
S650 Phosphorylation HPRD 17525332, 18077418
S653 Phosphorylation HPRD 20068231
S660 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S661 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 19415658, 20068231
S673 Phosphorylation HPRD 18669648
S674 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O94761 (RECQL4) S251 P49959 (MRE11) increased_association eFIP 29229926
Phosphorylation P49959 (MRE11) S558 Q9NWS0 (PIH1D1) unknown eFIP 28436950