iPTMnet Report for P49959 (MRE11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49959 / MRE11_HUMAN
Protein Name Double-strand break repair protein MRE11
Gene Name Name: MRE11
Synonyms:HNGS1,MRE11A;
Organism Homo sapiens (Human)

PRO ID PR:P49959
DAG View
PRO Name double-strand break repair protein MRE11 (human)
Definition A double-strand break repair protein MRE11 that is encoded in the genome of human.
Short Label hMRE11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49959 (MRE11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
T12 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
T74 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S158 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K255 Sumoylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
S264 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10608806
T272 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus   UniProt 23186163
K282 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S382 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus 10608806
K384 Ubiquitination PhosphoSitePlus
R388 Methylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K416 Acetylation PhosphoSitePlus
K416 Sumoylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K480 Acetylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
S531 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   RLIMS-P 26240375, 10608806
S558 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 28436950
S561 Phosphorylation PhosphoSitePlus   RLIMS-P 28436950
R570 Methylation PhosphoSitePlus
R572 Methylation PhosphoSitePlus
R574 Methylation PhosphoSitePlus
R576 Methylation PhosphoSitePlus
R577 Methylation PhosphoSitePlus
R580 Methylation PhosphoSitePlus
R587 Methylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus   RLIMS-P 26240375
R592 Methylation PhosphoSitePlus
R594 Methylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus   RLIMS-P 28967905
R604 Methylation PhosphoSitePlus
S605 O-Glycosylation GlyGen 23301498, 28411811, 35164752, ...35254053, 34019948, 32119511, 33465208
K609 Acetylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
R616 Methylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus   UniProt 23186163
K625 Sumoylation PhosphoSitePlus
S649 Phosphorylation P53350 (PLK1) , P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28512243, 18669648, 24275569, ...15845385, 19690332
S667 O-Glycosylation GlyGen 23301498, 28411811, 35164752, ...35254053, 34019948, 32119511, 33465208
S667 Phosphorylation PhosphoSitePlus
S668 O-Glycosylation GlyGen 23301498, 28411811, 35164752, ...35254053, 34019948, 32119511, 33465208
S668 Phosphorylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
S676 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P 26240375
S678 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26240375, 17525332, 23186163
S681 Phosphorylation PhosphoSitePlus
S688 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 23186163, ...17081983, 15302935, 18669648, 28436950, 24275569, 19690332, 20068231
S689 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 23186163, ...17081983, 15302935, 18669648, 28436950, 24275569, 19690332, 20068231
S701 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S702 Phosphorylation phospho.ELM 18669648
Site PTM Type PTM Enzyme Score Source PMID
T74 Phosphorylation HPRD 15302935
S264 Phosphorylation Q13315 (ATM) HPRD 10608806
S558 Phosphorylation HPRD 18669648, 18452278
T597 Phosphorylation HPRD 18212344
S602 Phosphorylation HPRD 17081983
T603 Phosphorylation HPRD 17081983
S619 Phosphorylation HPRD 18212344
S649 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T662 Phosphorylation HPRD 20068231
S667 Phosphorylation HPRD 20068231
S668 Phosphorylation HPRD 20068231
T669 Phosphorylation HPRD 20068231
S670 Phosphorylation HPRD 20068231
S671 Phosphorylation HPRD 20068231
S676 Phosphorylation HPRD 18077418
S678 Phosphorylation HPRD 17525332, 18077418
S681 Phosphorylation HPRD 20068231
S688 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S689 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 19415658, 20068231
S701 Phosphorylation HPRD 18669648
S702 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T74 Phosphorylation HPRD 15302935
S264 Phosphorylation Q13315 (ATM) HPRD 10608806
S558 Phosphorylation HPRD 18669648, 18452278
K597 Acetylation PhosphoSitePlus
S621 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T634 Phosphorylation HPRD 20068231
S639 Phosphorylation HPRD 20068231
S640 Phosphorylation HPRD 20068231
T641 Phosphorylation HPRD 20068231
S642 Phosphorylation HPRD 20068231
S643 Phosphorylation HPRD 20068231
S648 Phosphorylation HPRD 18077418
S650 Phosphorylation HPRD 17525332, 18077418
S653 Phosphorylation HPRD 20068231
S660 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S661 Phosphorylation HPRD 19413330, 18691976, 18491316, ...15302935, 18452278, 19651622, 18669648, 19415658, 20068231
S673 Phosphorylation HPRD 18669648
S674 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O94761 (RECQL4) S251 P49959 (MRE11) increased_association eFIP 29229926
Phosphorylation P49959 (MRE11) S558 Q9NWS0 (PIH1D1) unknown eFIP 28436950
Phosphorylation Q14191 (WRN) S1133 P49959 (MRE11) unknown eFIP 27634057


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y190 H190 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K196 N196 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K255 E255 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S273 F273 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K298 N298 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T329 I329 Biomuta DOID:4159 / skin cancer [ cosmic ]
R388 W388 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R388 Q388 Biomuta DOID:363 / uterine cancer [ icgc ]
K442 N442 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S447 L447 Biomuta [ cosmic ]
S531 Y531 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S558 F558 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S561 R561 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R570 K570 Biomuta DOID:1324 / lung cancer [ cosmic ]
R572 * Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R572 Q572 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R572 G572 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
R576 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R592 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R594 G594 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T603 I603 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R604 C604 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
R604 S604 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2021 / placenta cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K609 N609 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S613 P613 Biomuta DOID:363 / uterine cancer [ icgc ]
S621 L621 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S649 L649 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]