iPTMnet Report for P49917 (LIG4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49917 / DNLI4_HUMAN
Protein Name DNA ligase 4
Gene Name Name: LIG4
Organism Homo sapiens (Human)

PRO ID PR:P49917
DAG View
PRO Name DNA ligase 4 (human)
Definition A DNA ligase 4 that is encoded in the genome of human.
Short Label hLIG4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49917 (LIG4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R40 Methylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
C137 Methylation IEDB 31844290
K169 Ubiquitination PhosphoSitePlus
S199 Phosphorylation neXtProt   phospho.ELM 10608806
S199 Phosphorylation Q13315 (ATM) phospho.ELM 10608806
S199 Phosphorylation Q13535 (ATR) neXtProt 10608806
S267 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K432 Methylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K442 Methylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
T650 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   Signor 15194694
T650 Phosphorylation P78527 (PRKDC) HPRD   PhosphoSitePlus   Signor 15194694
S668 Phosphorylation Signor 15194694
S668 Phosphorylation P78527 (PRKDC) Signor 15194694
S672 Phosphorylation Signor 15194694
S672 Phosphorylation P78527 (PRKDC) Signor 15194694
K710 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
K890 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K169 N169 Biomuta DOID:1324 / lung cancer [ cosmic ]
T362 P362 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K432 N432 Biomuta DOID:1324 / lung cancer [ cosmic ]
K442 T442 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K571 N571 Biomuta DOID:1324 / lung cancer [ cosmic ]
K613 E613 Biomuta DOID:1324 / lung cancer [ cosmic ]
T650 N650 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K775 M775 Biomuta DOID:3571 / liver cancer [ cosmic ]