iPTMnet Report for P49916 (LIG3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49916 / DNLI3_HUMAN
Protein Name DNA ligase 3 precursor
Gene Name Name: LIG3
Organism Homo sapiens (Human)

PRO ID PR:P49916
DAG View
PRO Name DNA ligase 3 (human)
Definition A DNA ligase 3 that is encoded in the genome of human.
Short Label hLIG3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49916 (LIG3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K111 Acetylation PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
T178 O-Glycosylation GlyGen 33465208
S185 O-Glycosylation GlyGen 33465208
S186 O-Glycosylation GlyGen 33465208
T191 O-Glycosylation GlyGen 35138101, 30379171, 34019948, ...29485866, 28510447, 33465208
T191 Phosphorylation P06493 (CDK1) , P24941 (CDK2) PhosphoSitePlus 17040896
T204 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S210 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 16964243, ...17040896, 20068231
K213 Methylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus   UniProt 23186163
S227 Phosphorylation PhosphoSitePlus   UniProt 18669648
K232 Acetylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   UniProt 23186163
T244 Phosphorylation PhosphoSitePlus
S250 O-Glycosylation GlyGen 33465208
S251 O-Glycosylation GlyGen 35138101, 30379171, 34019948, ...29485866, 28510447, 33465208
S252 O-Glycosylation GlyGen 33465208
K316 Acetylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
T479 Phosphorylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
C611 Methylation IEDB 31844290
K615 Acetylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
T665 Phosphorylation PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
Y767 Phosphorylation PhosphoSitePlus
Y768 Phosphorylation PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
K817 Methylation PhosphoSitePlus
K817 Sumoylation PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
T877 Phosphorylation PhosphoSitePlus
K883 Acetylation PhosphoSitePlus
S889 Phosphorylation PhosphoSitePlus
S900 Phosphorylation PhosphoSitePlus
K907 Acetylation PhosphoSitePlus
T910 Phosphorylation PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
S913 Phosphorylation P06493 (CDK1) , P24941 (CDK2) PhosphoSitePlus   UniProt 23186163, 17040896
Site PTM Type PTM Enzyme Score Source PMID
T204 Phosphorylation HPRD 18669648, 20068231
T209 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231
S210 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 20058876, 19664995, 19651622, 18669648, 20068231, 20068230
S227 Phosphorylation HPRD 18669648
S236 Phosphorylation HPRD 19651622
S241 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231
S242 Phosphorylation HPRD 19413330, 19664995, 18452278, ...19651622, 18669648, 20068231
T244 Phosphorylation HPRD 19651622, 20068231, 18452278
S853 Phosphorylation HPRD 18669648
S913 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T204 Phosphorylation HPRD 18669648, 20068231
T209 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231
S210 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 20058876, 19664995, 19651622, 18669648, 20068231, 20068230
S227 Phosphorylation HPRD 18669648
S236 Phosphorylation HPRD 19651622
S241 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231
S242 Phosphorylation HPRD 19413330, 19664995, 18452278, ...19651622, 18669648, 20068231
T244 Phosphorylation HPRD 19651622, 20068231, 18452278
S853 Phosphorylation HPRD 18669648
S913 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T204 A204 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S236 C236 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S242 G242 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K316 R316 Biomuta DOID:1612 / breast cancer [ icgc ]
K463 N463 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S476 L476 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
K498 R498 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K498 T498 Biomuta DOID:363 / uterine cancer [ icgc ]
C611 Y611 Biomuta [ cosmic ]
T637 A637 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T647 S647 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T796 K796 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]