Protein Information

Cytoscape View


UniProt AC / UniProt ID P49915 / GUAA_HUMAN
Protein Name GMP synthase [glutamine-hydrolyzing]
Gene Name Name: GMPS
Organism Homo sapiens (Human)

PRO ID PR:P49915
DAG View
PRO Name GMP synthase [glutamine-hydrolyzing] (human)
Definition A GMP synthase [glutamine-hydrolyzing] that is encoded in the genome of human.
Short Label hGMPS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49915 (GMPS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S8 Phosphorylation PhosphoSitePlus   UniProt 23186163
K9 Acetylation PhosphoSitePlus   UniProt 19608861
K9 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K183 Acetylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S313 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T318 Phosphorylation P06493 (CDK1) , P24941 (CDK2) PhosphoSitePlus   UniProt 18847512, 18234856, 20068231
K325 Ubiquitination PhosphoSitePlus
T331 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
K336 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K389 Acetylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
R399 Methylation PhosphoSitePlus
K400 Acetylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K416 Acetylation PhosphoSitePlus
K416 Sumoylation PhosphoSitePlus
C449 S-Nitrosylation dbSNO 19483679
Y454 Phosphorylation PhosphoSitePlus
C456 S-Nitrosylation dbSNO 19483679
K457 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K487 Sumoylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
C523 S-Nitrosylation dbSNO 26338901
Y526 Phosphorylation PhosphoSitePlus
C530 S-Nitrosylation dbSNO 26338901
K535 Ubiquitination PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
T616 Phosphorylation PhosphoSitePlus
R622 Methylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T318 Phosphorylation HPRD 20068231, 17924679
T331 Phosphorylation HPRD 19651622, 18669648, 19664995, ...20068231
S332 Phosphorylation HPRD 19413330, 18767875, 18669648, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K120 T120 Biomuta DOID:363 / uterine cancer [ tcga ]
K204 N204 Biomuta DOID:363 / uterine cancer [ tcga ]
S282 F282 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S313 L313 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K412 T412 Biomuta DOID:363 / uterine cancer [ tcga ]
C456 F456 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc ]
K478 T478 Biomuta DOID:363 / uterine cancer [ tcga ]
Y526 C526 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K535 N535 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R622 Q622 Biomuta DOID:1909 / melanoma [ cosmic ]
R622 W622 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]