iPTMnet Report for P49914 (MTHFS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49914 / MTHFS_HUMAN
Protein Name 5-formyltetrahydrofolate cyclo-ligase
Gene Name Name: MTHFS
Organism Homo sapiens (Human)

PRO ID PR:P49914
DAG View
PRO Name 5-formyltetrahydrofolate cyclo-ligase (human)
Definition A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of human.
Short Label hMTHFS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49914 (MTHFS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S7 Phosphorylation PhosphoSitePlus
K10 Acetylation PhosphoSitePlus
K10 Sumoylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
C78 Methylation IEDB 31844290
Y83 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K150 Acetylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K158 Methylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y46 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 R7 Biomuta DOID:4159 / skin cancer [ icgc ]
K48 N48 Biomuta DOID:10534 / stomach cancer [ cosmic ]