iPTMnet Report for P49848 (TAF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49848 / TAF6_HUMAN
Protein Name Transcription initiation factor TFIID subunit 6
Gene Name Name: TAF6
Synonyms:TAF2E,TAFII70;
Organism Homo sapiens (Human)

PRO ID PR:P49848
DAG View
PRO Name transcription initiation factor TFIID subunit 6 (human)
Definition A transcription initiation factor TFIID subunit 6 that is encoded in the genome of human.
Short Label hTAF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49848 (TAF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K48 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
R95 Methylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus   UniProt 23186163
K193 Acetylation PhosphoSitePlus
K196 Sumoylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
K287 Methylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
T480 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T481 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 21606357, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T483 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T483 Phosphorylation PhosphoSitePlus
T485 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T490 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T492 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
S494 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
R502 Methylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
S512 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
S522 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
R524 Methylation PhosphoSitePlus   UniProt 24129315
S532 Phosphorylation PhosphoSitePlus
K537 Methylation PhosphoSitePlus
S586 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T589 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T590 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
S594 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T595 O-Glycosylation GlyGen 34846842, 33214551, 32938750, ...32870666, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
S598 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
S602 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
S602 Phosphorylation PhosphoSitePlus
Y606 Phosphorylation PhosphoSitePlus
T614 O-Glycosylation GlyGen 34846842, 33214551, 32870666, ...30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 35254053, 28657654, 29237092
T614 Phosphorylation PhosphoSitePlus
T622 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S626 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S633 Phosphorylation PhosphoSitePlus
S634 O-Glycosylation GlyGen 29351928
S634 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S636 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S639 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S653 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 24275569, 19690332
T660 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...24275569, 19690332
S670 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y606 Phosphorylation HPRD 19413330
T614 Phosphorylation HPRD 19413330
T622 Phosphorylation HPRD 19413330
S626 Phosphorylation HPRD 18669648
S634 Phosphorylation HPRD 18669648
S636 Phosphorylation HPRD 18669648
S653 Phosphorylation HPRD 19413330, 18669648, 15302935
T660 Phosphorylation HPRD 19413330, 18669648, 19664994, ...16964243
S670 Phosphorylation HPRD 19413330, 19664995
S672 Phosphorylation HPRD 19413330, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 T48 Biomuta DOID:5158 / pleural cancer [ cosmic ]
K65 E65 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K78 N78 Biomuta DOID:1612 / breast cancer [ cosmic ]
R95 L95 Biomuta DOID:1324 / lung cancer [ cosmic ]
K357 N357 Biomuta DOID:363 / uterine cancer [ icgc ]
T372 I372 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S425 N425 Biomuta DOID:363 / uterine cancer [ icgc ]
T480 A480 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T485 M485 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T490 K490 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R502 H502 Biomuta DOID:363 / uterine cancer [ icgc ]
R502 C502 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R524 L524 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T590 I590 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S672 C672 Biomuta DOID:1324 / lung cancer [ cosmic ]
S672 P672 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]