Protein Information

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UniProt AC / UniProt ID P49841 / GSK3B_HUMAN
Protein Name Glycogen synthase kinase-3 beta
Gene Name Name: GSK3B
Organism Homo sapiens (Human)

PRO ID PR:P49841
DAG View
PRO Name glycogen synthase kinase-3 beta (human)
Definition A glycogen synthase kinase-3 beta that is encoded in the genome of human.
Short Label hGSK3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49841 (GSK3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 29377106
T8 Phosphorylation PhosphoSitePlus   RLIMS-P 29377106
S9 Phosphorylation P05129 (PRKCG) , Q05513 (PRKCZ) , P31751 (AKT2) , Q9Y4K4 (MAP4K5) , Q9UM73 (ALK) , O14965 (AURKA) , P23443 (RPS6KB1) , Q13237 (PRKG2) , P05771 (PRKCB) , P51812 (RPS6KA3) , Q9UBS0 (RPS6KB2) , P49841 (GSK3B) , P24723 (PRKCH) , P17612 (PRKACA) , O94806 (PRKD3) , Q05655 (PRKCD) , P31749 (AKT1) , P17252 (PRKCA) , Q15831 (STK11) , Q15418 (RPS6KA1) , Q9Y243 (AKT3) , Q96BR1 (SGK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 26097594, 29290948, 30502054, ...23829535, 26714756, 31150511, 29258530, 25622969, 22310719, 22721429, 26441681, 14657655, 28335557, 27123999, 28591721, 29382851, 22683934, 25687330, 25169422, 19903789, 23941783, 20926391, 23211630, 23408967, 26621838, 19506320, 29725502, 25344882, 27077117, 26631736, 29550832, 23846217, 24165455, 26863455, 25683913, 29298655, 18041091, 17982039, 24987368, 27494834, 25246272, 28495797, 29433844, 23979838, 26484916, 25691573, 25541965, 29383135, 25880247, 29449801, 11884598, 24831601, 29049420, 25138042, 26648168, 23951306, 24055036, 26119563, 31119584, 15684397, 10913153, 27258307, 26910283, 16484360, 26915040, 26711256, 27793695, 21504119, 26942699, 22622071, 30534418, 22710759, 26421002, 19382207, 16397900, 19778547, 27163678, 17317006, 25880337, 21329734, 31005954, 11035810, 30242258, 24571487, 20548028, 25701004, 21887250, 25603341, 18660440, 15799972, 2475737, 28574827, 22372491, 24675460, 30728908, 21296133, 25115395, 26974342, 27762303, 15735754, 28694515, 29665837, 30238389, 16914735, 21297267, 27907035, 20352103, 24337584, 12598741, 23552696, 25361010, 22179823, 29981053, 25385175, 18508033, 19836308, 29159980, 26374165, 25296946, 27654922, 23123500, 21152425, 19079342, 31139591, 26093674, 31099187, 18793648, 17595317, 26087957, 21189258, 27007368, 23618343, 10873588, 29463070, 7980435, 29805694, 26388612, 23418486, 24391509, 25002914, 8772194, 23565238, 23453973, 27235578, 21334395, 27977752, 26400473, 30486290, 30523261, 11331582, 14713298, 28473749, 23646926, 31355268, 16987962, 24248537, 20432447, 31138169, 23440295, 30843345, 17289399, 28762556, 22751450, 29163781, 23085082, 18805899, 15265592, 15339992, 20205745, 26521017, 17192257, 18316598, 19714564, 20144629, 28630356, 30013652, 26551701, 19966058, 26085927, 29844403, 20599907, 25764078, 21837363, 16799642, 18769147, 25219467, 26320152, 31105527, 27901475, 15457186, 24884462, 17495324, 27239959, 25849320, 9373175, 15132987, 17961557, 26674355, 19060929, 23050041, 25104922, 26972480, 11389054, 22470507, 28267204, 12091467, 15805245, 20231273, 31412932, 16055922, 25104312, 27328758, 30819803, 27350769, 18407462, 21949350, 26246283, 30123074, 21935433, 28703798, 18669648, 16204075, 25412347, 26115843, 20090934, 28099142, 22180352, 26416449, 31057052, 27713242, 28480051, 24086147, 11584304, 20576277, 21060752, 22347457, 21643720, 24073285, 14988008, 19126599, 25899925, 29434807, 29775963, 21320285, 26333042, 23874982, 24232259, 25568334, 23559006, 30275459, 17200689, 23646150, 27040177, 30683932, 27015122, 26061531, 19659461, 25963821, 24893131, 29949874, 29563926, 20026151, 23948896, 27219337, 20696143, 26560046, 22496446, 28217097, 21931595, 25632187, 25641096, 23874688, 28594934, 27924507, 30352794, 16543730, 12054501, 26739349, 25622907, 11495916, 12393899, 25360740, 27783993, 29377106, 16484495, 20031160, 24586346, 18577697, 26385055, 27379018, 21890631, 28475144, 23010592, 23208610, 21447180, 11563975, 29212798, 22363707, 23325562, 11746362, 17804190, 29930281, 17951252, 28967903, 23575666, 30258898, 21207227, 29179438, 18353303, 19819952, 25941936, 11579131, 20952497, 30678307, 27636107, 27835591, 21879332, 26284031, 31017040, 16987250, 22893788, 22355693, 23332125, 21439087, 16806104, 26460618, 29789524, 31264276, 29196265, 30143583, 24910204, 15456937, 23919615, 11577096, 12900420, 18426604, 21826707, 26994872, 19786063, 22193544, 24142090, 28446231, 25986948, 24581171, 25451258, 26638989, 26311045, 20153492, 28614631, 30343126, 19116273, 30899395, 29940988, 22110662, 29700308, 28185129, 22956257, 29182558, 23077641, 19033378, 29992949, 30709379, 17638069, 24549719, 29137265, 15475000, 28114284, 19043530, 29445107, 30072894, 27221778, 24188406, 25966642, 29043099, 24577092, 25834400, 23284807, 21277352, 28549350, 26004524, 28518144, 25499217, 22142471, 18217188, 19681904, 27909397, 25522429, 16039586, 28697793, 28764929, 21711903, 23077590, 22534782, 28151479, 27094783, 27644877, 22536363, 23772367, 17008323, 11340086, 29069835, 17990294, 23673211, 26402673, 20592207, 18467524, 29921293, 27036017, 20831597, 25940701, 21229324, 30666163, 25909283, 30221686, 18582478, 26243309, 25120104, 20937854, 29257079, 25390651, 11779850, 26280348, 22496417, 30831484, 21565140, 31086815, 8985174, 8250835, 26637371, 27752740, 28575066, 23142521, 22975711, 21996745, 18551195, 26252009, 27122540, 29540196, 18757413, 21044952, 24037783, 28926938, 21360572, 24662831, 22810307, 26443198, 24312592, 28903391, 21448924, 25412261, 23582741, 26010513, 29393871, 23280703, 27579985, 21952626, 12504922, 24407515, 23667667, 27551464, 25089827, 26935904, 17148450, 24444018, 11583116, 18609681, 21422248, 30581378
S13 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S21 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 23565238, 22347457, 12054501, ...26402673, 16484360, 26284031
S25 Phosphorylation PhosphoSitePlus
K27 Methylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
T43 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16039586
S66 Phosphorylation PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
S147 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus   RLIMS-P 26711256
K183 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
K205 Acetylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation P49841 (GSK3B) , Q02750 (MAP2K1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 15265592, 15132987, 21504119, ...23897984, 12554650, 21360572, 25667991, 20831597, 26061531, 11738041, 17192257, 30201862, 17148450, 17403689, 20854473, 21297267, 12393899, 25002914, 24086147, 23565238, 14561750, 29844403, 26085927, 14617795, 29449568, 14988390, 18669648, 19111579, 28630356, 15020233, 18547980, 24685625, 21980429, 26648536, 21439087, 19188159, 19430525, 22041920, 25301365, 30581378, 19903789, 22998728, 18508033, 28824887, 27752740, 16964243, 17188038, 21887250, 19607922, 28663724, 28473749, 27343974, 23646926, 25169422, 23211630, 23408967, 24521712, 23959174, 28485728, 27195613, 14570592, 22536363, 26556864, 22355693, 17081983, 26246283, 19542364, 25522429, 23559006, 25632187, 20331603, 18655171, 21207227, 26274564, 18083107, 30275459, 27924507, 30709379, 24038789, 29073967, 29249966
S219 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
K292 Sumoylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
C317 S-Nitrosylation dbSNO 2212679, 22126794
K349 Ubiquitination PhosphoSitePlus
S389 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus   RLIMS-P   Signor 18451303, 22039048, 22496446, ...29382851, 17726008, 25349993
T390 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18451303, 22279539, ...21303975, 17192257, 18669648, 26674355
T392 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T395 Phosphorylation PhosphoSitePlus
T402 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 15302935
S417 Phosphorylation PhosphoSitePlus
T420 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation HPRD 18691976, 18669648, 20068231
S9 Phosphorylation P31749 (AKT1) , Q96BR1 (SGK3) , P17612 (PRKACA) HPRD   PhosphoSitePlus 18691976, 18669648, 12054501
S21 Phosphorylation Q96BR1 (SGK3) HPRD 18691976, 12054501
S215 Phosphorylation HPRD 17081983, 20068231
Y216 Phosphorylation P49841-2 (GSK3B) HPRD   PhosphoSitePlus 17016520, 16964243, 18691976, ...19664995, 18452278, 19607922, 18669648, 19901323, 8382613, 20068231, 16497976
S219 Phosphorylation HPRD 18691976, 20068231
T275 Phosphorylation HPRD 18691976
T277 Phosphorylation HPRD 18691976
S402 Phosphorylation HPRD 18691976, 15345747, 20068231
T403 Phosphorylation HPRD 18691976, 18669648, 15302935
T405 Phosphorylation HPRD 18691976, 18669648
T415 Phosphorylation HPRD 18691976
S426 Phosphorylation HPRD 18691976
S428 Phosphorylation HPRD 18691976
S432 Phosphorylation HPRD 18691976


P49841 (GSK3B) as PTM Enzyme



Substrate Site Score Source PMID
E9PAV3 (NACA) T2022 PhosphoSitePlus   Signor 15005626
O00327 (ARNTL) S17 PhosphoSitePlus   Signor 20049328
O00327 (ARNTL) T21 PhosphoSitePlus   Signor 20049328
O00429 (DNM1L) S40 PhosphoSitePlus 25192600
O00429 (DNM1L) S44 PhosphoSitePlus 25192600
O00429 (DNM1L) S693 PhosphoSitePlus 23185298
O15169 (AXIN1) T481 neXtProt   Signor 10581160
O15169 (AXIN1) S486 neXtProt   Signor 10581160
O15169-1 (AXIN1) S614 HPRD 10581160
O15294 (OGT) S3 PhosphoSitePlus 23395175
O15294 (OGT) S4 PhosphoSitePlus 23395175
O15516 (CLOCK) S427 PhosphoSitePlus 19946213
O43602-2 (DCX) S327 PhosphoSitePlus 21159948
O43602 (DCX) S332 Signor 21159948
O43623 (SNAI2) S92 PhosphoSitePlus 22727060, 23851495
O43623 (SNAI2) S96 PhosphoSitePlus 22727060, 23851495
O43623 (SNAI2) S100 PhosphoSitePlus 22727060, 23851495
O43623 (SNAI2) S104 PhosphoSitePlus 22727060, 23851495
O60341 (KDM1A) S683 RLIMS-P+ 27501329
O60346 (PHLPP1) S1359 PhosphoSitePlus   Signor 19797085
O60346 (PHLPP1) T1363 PhosphoSitePlus 19797085
O60346 (PHLPP1) S1379 PhosphoSitePlus 19797085
O60346 (PHLPP1) S1381 PhosphoSitePlus 19797085
O60716-6 (CTNND1) S252 HPRD 20166139, 12885254, 18212344
O60716-6 (CTNND1) T310 HPRD 12885254
O75030-10 (MITF) S292 HPRD 10587587
O75030-9 (MITF) S298 HPRD   PhosphoSitePlus 10587587
O75030-8 (MITF) S383 HPRD 10587587
O75030-9 (MITF) S397 PhosphoSitePlus 25605940
O75030-6 (MITF) S398 HPRD 10587587
O75030-2 (MITF) S399 HPRD 10587587
O75030-9 (MITF) S401 PhosphoSitePlus 25605940
O75030-9 (MITF) S405 PhosphoSitePlus 25605940
O75122 (CLASP2) S499 PhosphoSitePlus 22467876
O75122 (CLASP2) S503 PhosphoSitePlus 22467876
O75122 (CLASP2) S507 PhosphoSitePlus 22467876
O75122 (CLASP2) S533 PhosphoSitePlus 19638411
O75122 (CLASP2) S537 PhosphoSitePlus 19638411
O75581 (LRP6) S1490 HPRD   PhosphoSitePlus   Signor 16365045, 16890161, 16341017
O75581 (LRP6) T1572 HPRD 16365045
O75581 (LRP6) S1607 HPRD 16365045
O75925 (PIAS1) S17 PhosphoSitePlus 26157031
O75952-5 (CABYR) T53 HPRD 15752768
O75952-5 (CABYR) S57 HPRD 15752768
O75952-2 (CABYR) T133 HPRD 15752768
O75952-2 (CABYR) S137 HPRD 15752768
O75952-1 (CABYR) T151 HPRD   neXtProt   PhosphoSitePlus 15752768
O75952 (CABYR) S155 HPRD   neXtProt   PhosphoSitePlus 15752768
O95271 (TNKS) S978 PhosphoSitePlus 17026964
O95271 (TNKS) T982 PhosphoSitePlus 17026964
O95271 (TNKS) S987 PhosphoSitePlus 17026964
O95271 (TNKS) S991 PhosphoSitePlus 17026964
O95863 (SNAI1) S92 neXtProt 15448698
O95863 (SNAI1) S96 neXtProt   PhosphoSitePlus   Signor 19004823, 20305697, 15448698
O95863 (SNAI1) S100 PhosphoSitePlus   Signor 20305697, 19004823, 15448698
O95863 (SNAI1) S104 PhosphoSitePlus   Signor 20305697, 15448698, 15647282
O95863 (SNAI1) S107 PhosphoSitePlus   Signor 19004823, 20305697, 15448698, ...15647282
O95863 (SNAI1) S111 PhosphoSitePlus   Signor 19004823, 20305697, 15448698
O95863 (SNAI1) S115 PhosphoSitePlus   Signor 19004823, 20305697, 15448698
O95863 (SNAI1) S119 PhosphoSitePlus   Signor 20305697, 19004823, 15448698
P01106 (MYC) T58 PhosphoSitePlus   Signor 14563837, 16023596, 15150404
P01106-2 (MYC) T73 HPRD 19651622, 2663470, 18669648, ...20068231
P01112 (HRAS) T144 PhosphoSitePlus 22494971
P01112 (HRAS) T148 PhosphoSitePlus 22494971
P03372 (ESR1) S102 PhosphoSitePlus   Signor 16076840
P03372 (ESR1) S104 PhosphoSitePlus   Signor 18372406, 16076840
P03372 (ESR1) S106 PhosphoSitePlus   Signor 18372406, 16076840
P03372 (ESR1) S118 PhosphoSitePlus   RLIMS-P+   Signor 17609434, 16076840
P04150 (NR3C1) S404 PhosphoSitePlus   Signor 18838540
P04637 (TP53) S33 HPRD   Signor 11483158, 12064478
P04637 (TP53) S376 PhosphoSitePlus 14744935
P05067-4 (APP) T668 HPRD 8764598, 15178331, 10936190
P05067-8 (APP) T724 HPRD 8764598, 15178331, 10936190
P05067-1 (APP) T743 HPRD 8764598, 15178331, 10936190
P05412 (JUN) T239 PhosphoSitePlus   Signor 16023596, 1846781
P05412 (JUN) S243 PhosphoSitePlus   Signor 16023596, 1846781, 17215518
P06401-2 (PGR) S390 PhosphoSitePlus 23880761
P08047 (SP1) S728 RLIMS-P+ 19372209
P08047 (SP1) S732 RLIMS-P+ 19372209
P10070 (GLI2) S820 Signor 16611981
P10070 (GLI2) S832 Signor 16611981
P10070 (GLI2) S863 Signor 16611981
P10636-8 (MAPT) S46 PhosphoSitePlus 9614189
P10636-8 (MAPT) T50 PhosphoSitePlus 9614189
P10636-2 (MAPT) T123 HPRD 11181841, 7566346, 9771888, ...9832145, 18510355, 9199504
P10636-2 (MAPT) S126 HPRD 12387894, 9771888
P10636-6 (MAPT) S137 HPRD 11181841, 12387894, 9771888
P10636-2 (MAPT) S140 HPRD 7566346, 9832145, 12387894, ...9771888
P10636-2 (MAPT) S141 HPRD 19413330, 9565682, 7566346, ...12387894, 9771888
P10636-6 (MAPT) S144 HPRD 19413330, 9771888, 7566346, ...12226093, 1330687, 12387894, 19415658, 9565682, 9832145, 9199504
P10636-2 (MAPT) T147 HPRD 19413330, 9546672, 11181841, ...19562805, 9199504, 12226093, 12387894, 9565682, 9832145, 9771888, 12435421
P10636-2 (MAPT) S150 HPRD 19562805, 11311121
P10636-8 (MAPT) T153 PhosphoSitePlus 10090741
P10636-6 (MAPT) T154 HPRD 9546672, 11181841, 12387894, ...11311121, 9832145, 9353289
P10636-6 (MAPT) T159 HPRD 7566346, 9832145, 12387894, ...11181841
P10636-2 (MAPT) T173 HPRD 19651622, 17287340, 9771888, ...9199504, 12387894, 9565682, 9832145, 9353289, 9735171, 7566346, 20068231
P10636-8 (MAPT) T175 PhosphoSitePlus 10090741
P10636-8 (MAPT) T181 HPRD   PhosphoSitePlus 18052981, 11181841, 7566346, ...9771888, 12387894, 17078951, 9832145, 18510355, 9199504
P10636-8 (MAPT) S195 HPRD   PhosphoSitePlus 11181841, 20679343, 12387894, ...9771888
P10636-8 (MAPT) S198 HPRD 7566346, 9832145, 12387894, ...9771888
P10636-8 (MAPT) S199 HPRD   PhosphoSitePlus 19413330, 18052981, 20679343, ...9771888, 7566346, 12387894, 9565682, 17078951, 16257959, 20308788
P10636-8 (MAPT) S202 HPRD   PhosphoSitePlus 19413330, 18052981, 9771888, ...7566346, 12226093, 1330687, 12387894, 19415658, 9565682, 9832145, 17078951, 20308788, 9199504
P10636-6 (MAPT) S204 HPRD 8999860, 9771888, 10090741, ...12387894, 9832145, 7706316, 9735171
P10636-8 (MAPT) T205 HPRD   PhosphoSitePlus 19413330, 18052981, 20679343, ...11181841, 19562805, 9199504, 12226093, 12387894, 9565682, 17078951, 9771888, 20308788
P10636-8 (MAPT) S208 HPRD 19562805, 11311121
P10636-8 (MAPT) S210 PhosphoSitePlus 20679343
P10636-8 (MAPT) T212 HPRD   PhosphoSitePlus 18052981, 9546672, 16987243, ...11181841, 10090741, 9353289, 12387894, 11311121, 15542598, 9832145, 17078951, 20308788
P10636-8 (MAPT) S214 PhosphoSitePlus 17078951, 20679343, 12387894
P10636-8 (MAPT) T217 HPRD   PhosphoSitePlus 18052981, 16987243, 9771888, ...10090741, 7566346, 11181841, 12387894, 9832145, 17078951, 20308788, 9199504
P10636-8 (MAPT) T231 HPRD   PhosphoSitePlus 18052981, 19651622, 15542598, ...17287340, 18055457, 9771888, 10090741, 7566346, 12387894, 17045592, 9565682, 17078951, 9832145, 25573097, 9353289, 9735171, 9199504, 20068231
P10636-8 (MAPT) S235 PhosphoSitePlus 10090741
P10636-8 (MAPT) S262 HPRD   PhosphoSitePlus 8999860, 9771888, 10090741, ...12387894, 9832145, 7706316, 15652175, 17078951, 9735171, 20308788
P10636-2 (MAPT) S307 HPRD 9565682, 7566346, 9832145, ...12387894, 1181841
P10636-2 (MAPT) S311 HPRD 19413330, 7566346, 9832145, ...12387894
P10636-2 (MAPT) S315 HPRD 19413330, 19651622, 9771888, ...7566346, 11181841, 12387894, 9565682, 9832145, 19415658
P10636-2 (MAPT) S324 HPRD 9565682, 12387894
P10636-6 (MAPT) S338 HPRD 9565682, 7566346, 9832145, ...12387894, 1181841
P10636-6 (MAPT) S342 HPRD 19413330, 7566346, 9832145, ...12387894
P10636-6 (MAPT) S346 HPRD 19413330, 19651622, 9771888, ...7566346, 11181841, 12387894, 9565682, 9832145, 19415658
P10636 (MAPT) S396 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 18052981, 20679343, 10090741, ...7566346, 1181841, 12387894, 9565682, 15542598, 9832145, 16519507, 16478768, 17078951, 20080974, 20308788, 18055457
P10636 (MAPT) S400 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 19413330, 20679343, 7566346, ...16519507, 9832145, 12387894, 16478768
P10636-8 (MAPT) S404 HPRD   PhosphoSitePlus 19413330, 19651622, 20679343, ...18052981, 9771888, 10090741, 7566346, 11181841, 9614189, 12387894, 18055457, 9565682, 15542598, 9832145, 17078951, 20080974, 16257959, 20308788, 19415658
P10636-8 (MAPT) S409 PhosphoSitePlus 17078951
P10636-8 (MAPT) S413 HPRD 9565682, 12387894
P10636-8 (MAPT) S422 PhosphoSitePlus 17078951
P10636 (MAPT) T498 Signor 12387894
P10636 (MAPT) S512 Signor 9771888
P10636 (MAPT) S515 Signor 9832145
P10636 (MAPT) S516 Signor 20308788, 12387894
P10636 (MAPT) S519 Signor 17078951, 12387894
P10636 (MAPT) T522 Signor 20308788, 12387894
P10636 (MAPT) T529 Signor 12387894
P10636 (MAPT) S531 Signor 12387894
P10636 (MAPT) T534 Signor 17078951, 12387894
P10636 (MAPT) T548 neXtProt   Signor 14690523, 21215781, 12387894
P10636 (MAPT) S579 Signor 21215781, 9771888
P10636 (MAPT) S713 Signor 12387894
P10636 (MAPT) S717 Signor 12387894
P10636 (MAPT) S721 Signor 20679343, 12387894
P11388 (TOP2A) S1361 PhosphoSitePlus 21254166
P12036 (NEFH) S503 PhosphoSitePlus   Signor 12130654, 19530163
P12524 (MYCL) S38 PhosphoSitePlus 1312697
P12524 (MYCL) S42 PhosphoSitePlus 1312697
P12830-1 (CDH1) S847 HPRD 10671552
P13807-1 (GYS1) S641 HPRD   neXtProt   Signor 11427888, 18669648, 15791206, ...14593110, 6772446
P13807-1 (GYS1) S645 HPRD   neXtProt   PhosphoSitePlus 18691976, 19664994, 15791206, ...6772446, 18669648, 11427888, 14680475
P13807-1 (GYS1) S649 HPRD 11427888, 18669648, 6772446
P13807-1 (GYS1) S653 HPRD   PhosphoSitePlus 19651622, 2117608, 14680475
P15924 (DSP) S2845 PhosphoSitePlus 25733715
P15924 (DSP) S2849 PhosphoSitePlus 25733715
P15941-7 (MUC1) S227 HPRD 9819408
P15941-11 (MUC1) S236 HPRD 9819408
P15941-8 (MUC1) S245 HPRD 9819408
P15941 (MUC1) S1227 neXtProt   PhosphoSitePlus 9819408
P16220-2 (CREB1) S115 HPRD 12162494
P16220-1 (CREB1) S129 HPRD   PhosphoSitePlus 12162494, 20541704
P16401 (H1-5) T11 PhosphoSitePlus   Signor 19136008
P16471 (PRLR) S349 RLIMS-P+ 18316598
P17275 (JUNB) S251 PhosphoSitePlus 22710716
P17275 (JUNB) T255 PhosphoSitePlus 22710716
P17676 (CEBPB) S223 PhosphoSitePlus 22080951
P17676 (CEBPB) T226 Signor 22369944
P17676 (CEBPB) S231 Signor 22369944, 17601773
P19838-2 (NFKB1) S900 HPRD 11425860
P19838-2 (NFKB1) S904 HPRD 18669648, 11425860
P19838-2 (NFKB1) S908 HPRD 18669648, 11425860
P20393 (NR1D1) S55 PhosphoSitePlus   Signor 16484495
P20393 (NR1D1) S59 PhosphoSitePlus   Signor 16484495
P22670 (RFX1) S120 PhosphoSitePlus 26041775
P22670 (RFX1) T124 PhosphoSitePlus 26041775
P23246 (SFPQ) T687 PhosphoSitePlus   Signor 20932480
P23760 (PAX3) S201 RLIMS-P+ 23058914
P24385 (CCND1) T286 HPRD   neXtProt   PhosphoSitePlus   Signor 10910956, 10766840, 16504004, ...17046823, 23552696, 16732330, 9832503
P24385 (CCND1) T288 RLIMS-P+ 17046823
P24864 (CCNE1) S73 PhosphoSitePlus 14536078
P24864 (CCNE1) T77 PhosphoSitePlus   Signor 14536078
P24864-1 (CCNE1) T395 HPRD   PhosphoSitePlus   Signor 14536078, 18691976, 8861947
P25054-1 (APC) S1501 HPRD   PhosphoSitePlus 17910481, 15327768
P25054 (APC) S1503 HPRD   PhosphoSitePlus 17910481, 15327768
P30279 (CCND2) T280 PhosphoSitePlus   Signor 17486076, 24705253
P30281 (CCND3) T283 PhosphoSitePlus   Signor 16331257, 15252116
P30291 (WEE1) S211 PhosphoSitePlus 24817118
P30304 (CDC25A) S76 PhosphoSitePlus   Signor 20348946, 18167338
P33076 (CIITA) S373 PhosphoSitePlus   Signor 17991736
P35222 (CTNNB1) S33 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 11955436, 19061640, 12000790, ...23151663, 16293724, 19303846, 11818547, 11967263, 16199882, 19293931, 12114015
P35222 (CTNNB1) S37 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 11955436, 12114015, 12000790, ...16293724, 19303846, 11818547, 11967263, 16199882, 19293931, 19061640
P35222 (CTNNB1) T41 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 11955436, 12114015, 12051714, ...11967263, 23151663, 16293724, 19303846, 11818547, 12000790, 16199882, 19293931
P35612 (ADD2) S613 PhosphoSitePlus 21606488
P35612 (ADD2) S693 PhosphoSitePlus 21606488
P36956 (SREBF1) T426 PhosphoSitePlus   Signor 19126544, 16825193
P36956 (SREBF1) S430 PhosphoSitePlus   Signor 19126544, 16825193
P36956 (SREBF1) S434 PhosphoSitePlus   Signor 19126544
P37840 (SNCA) S129 PhosphoSitePlus 25394490
P38936 (CDKN1A) T57 PhosphoSitePlus 11779850
P38936 (CDKN1A) S114 PhosphoSitePlus   Signor 17283049
P40337 (VHL) S68 PhosphoSitePlus 16847331
P41236 (PPP1R2) T73 HPRD   PhosphoSitePlus 12761178, 12697755, 11320080, ...26655089
P49715-1 (CEBPA) T226 HPRD 10567568
P49715-1 (CEBPA) T230 HPRD 10567568
P49716 (CEBPD) S167 PhosphoSitePlus 23993701
P49768 (PSEN1) S353 HPRD   PhosphoSitePlus   Signor 11104755, 17389597, 17360711
P49768 (PSEN1) S357 HPRD   PhosphoSitePlus   Signor 11104755, 17389597, 17360711
P49841 (GSK3B) S9 RLIMS-P+ 24444018, 18793648
P49841 (GSK3B) Y216 PhosphoSitePlus   RLIMS-P+   Signor 26648536, 19607922, 17188038, ...20331603, 14570592
P50219 (MNX1) S77 Signor 24425879
P50219 (MNX1) S79 Signor 24425879
P50895 (BCAM) S596 PhosphoSitePlus 15975931
P53396-2 (ACLY) T447 HPRD 10653665, 20058876
P53396-2 (ACLY) S451 HPRD 10653665
P53805-4 (RCAN1) S28 HPRD 19651622, 12063245, 20068231
P53805-2 (RCAN1) S108 HPRD 19651622, 12063245, 20068231
P53805 (RCAN1) S163 HPRD   PhosphoSitePlus 19651622, 12063245, 21965663, ...20068231
P54132 (BLM) T171 PhosphoSitePlus 26028025
P54252 (ATXN3) S256 PhosphoSitePlus 17434145
P56524 (HDAC4) S298 PhosphoSitePlus   Signor 21118993
P56524 (HDAC4) S302 PhosphoSitePlus   Signor 21118993
P57059 (SIK1) T182 RLIMS-P+ 18348280
P58012 (FOXL2) S33 PhosphoSitePlus 24390485
P60484 (PTEN) S362 PhosphoSitePlus 16107342
P60484 (PTEN) T366 PhosphoSitePlus   Signor 16107342
P84022 (SMAD3) T66 Signor 18172167
Q00613 (HSF1) S303 PhosphoSitePlus   Signor 8940068
Q00653 (NFKB2) S222 PhosphoSitePlus 20513428
Q00653 (NFKB2) S707 PhosphoSitePlus 22388891, 22864569
Q00653 (NFKB2) S711 PhosphoSitePlus 22388891, 22864569
Q01094 (E2F1) S403 PhosphoSitePlus 20447425, 17050006
Q01094 (E2F1) T433 PhosphoSitePlus 17050006
Q01201 (RELB) S573 PhosphoSitePlus 21217772
Q01974 (ROR2) S864 Signor 21078818
Q02156 (PRKCE) S346 PhosphoSitePlus   Signor 18604201
Q03060-16 (CREM) S83 HPRD 8404858
Q04206 (RELA) S468 PhosphoSitePlus   Signor 15465828, 16407239, 18201972, ...17183360
Q04721 (NOTCH2) T2068 HPRD   Signor 12794074
Q04721 (NOTCH2) S2070 HPRD   Signor 12794074, 18669648, 15302935, ...20068231
Q04721 (NOTCH2) T2074 HPRD   Signor 12794074, 18669648
Q04721 (NOTCH2) S2093 HPRD   Signor 12794074
Q07812 (BAX) S163 PhosphoSitePlus   Signor 15525785
Q07817 (BCL2L1) S62 PhosphoSitePlus 22617334
Q07820-1 (MCL1) S159 HPRD   PhosphoSitePlus   Signor 16543145
Q07820-1 (MCL1) T163 HPRD 16543145
Q12778 (FOXO1) S325 HPRD 11980723
Q13131 (PRKAA1) S486 PhosphoSitePlus 23623684
Q13131 (PRKAA1) T490 PhosphoSitePlus 23623684
Q13144 (EIF2B5) S535 HPRD 12133000
Q13144 (EIF2B5) S540 HPRD   Signor 18701453, 11500362, 9468292
Q13144 (EIF2B5) S544 HPRD 19413330, 18691976, 18088087, ...15302935, 19664994, 19007248, 18452278, 19651622, 18669648, 18707149, 20166139, 11500362, 20068231
Q13541 (EIF4EBP1) T37 PhosphoSitePlus   Signor 18701453, 23584478
Q13541 (EIF4EBP1) T46 PhosphoSitePlus   Signor 18701453, 23584478
Q13887 (KLF5) S303 PhosphoSitePlus   Signor 20484041, 24398687
Q14103-3 (HNRNPD) S83 HPRD   PhosphoSitePlus   Signor 19413330, 18691976, 17287340, ...18212344, 11903055, 18452278, 19651622, 12819195, 18669648, 20166139, 12819194, 19415658, 20068231, 20068230
Q14194 (CRMP1) T509 Signor 16611631
Q14194 (CRMP1) T514 Signor 16611631
Q14194 (CRMP1) S518 Signor 16611631
Q14195 (DPYSL3) T509 PhosphoSitePlus 15466863
Q14195 (DPYSL3) T514 PhosphoSitePlus 15466863
Q14195 (DPYSL3) S518 PhosphoSitePlus 15466863
Q14494 (NFE2L1) S379 PhosphoSitePlus   Signor 23623971
Q14896 (MYBPC3) S133 PhosphoSitePlus 23277198
Q15208 (STK38) S6 PhosphoSitePlus 22142472
Q15208 (STK38) T7 PhosphoSitePlus 22142472
Q15746 (MYLK) S1776 PhosphoSitePlus 15310280, 11964068
Q15797 (SMAD1) T202 PhosphoSitePlus 17289590
Q15853 (USF2) S155 PhosphoSitePlus 25238393
Q15853 (USF2) T230 PhosphoSitePlus 25238393
Q15910 (EZH2) S363 RLIMS-P+ 27494834
Q15910 (EZH2) T367 RLIMS-P+ 27494834
Q16236 (NFE2L2) S344 PhosphoSitePlus 22751928
Q16236 (NFE2L2) S347 PhosphoSitePlus 22751928
Q16555 (DPYSL2) T509 PhosphoSitePlus 15466863
Q16555 (DPYSL2) T514 HPRD   PhosphoSitePlus   RLIMS-P+ 19413330, 18491316, 16964243, ...15466863, 15483118, 19651622, 18669648, 15652488
Q16555 (DPYSL2) S518 PhosphoSitePlus   RLIMS-P+ 15483118, 17902168, 15466863
Q6PGQ7 (BORA) S274 PhosphoSitePlus   Signor 23442801
Q6PGQ7 (BORA) S278 PhosphoSitePlus   Signor 23442801
Q6R327 (RICTOR) S1235 PhosphoSitePlus 21343617
Q6R327 (RICTOR) T1695 PhosphoSitePlus 25897075
Q7KZI7 (MARK2) S212 neXtProt   PhosphoSitePlus 16257959, 18424437
Q8IZQ8 (MYOCD) S451 HPRD   Signor 16141410
Q8IZQ8-1 (MYOCD) S455 HPRD   Signor 16141410
Q8IZQ8-1 (MYOCD) S459 HPRD   Signor 16141410
Q8IZQ8 (MYOCD) S463 Signor 16141410
Q8IZQ8-1 (MYOCD) S626 HPRD   Signor 16141410
Q8IZQ8 (MYOCD) S630 HPRD   Signor 16141410
Q8IZQ8-1 (MYOCD) S634 HPRD   Signor 16141410
Q8IZQ8 (MYOCD) S638 Signor 16141410
Q8N122 (RPTOR) S722 PhosphoSitePlus 26348909
Q8N122 (RPTOR) S792 PhosphoSitePlus 26348909
Q8N122 (RPTOR) S859 PhosphoSitePlus 26348909
Q8N122 (RPTOR) S863 PhosphoSitePlus 26348909
Q8N122 (RPTOR) S877 PhosphoSitePlus 26348909
Q8NHW3 (MAFA) S49 Signor 18042454
Q8NHW3 (MAFA) T53 Signor 18042454
Q8NHW3 (MAFA) T57 Signor 18042454
Q8NHW3 (MAFA) S61 Signor 18042454
Q92597 (NDRG1) S342 neXtProt 15461589
Q92597 (NDRG1) S352 neXtProt 15461589
Q92597 (NDRG1) S362 neXtProt 15461589
Q92837 (FRAT1) S188 PhosphoSitePlus 16982607
Q92993 (KAT5) S86 PhosphoSitePlus   Signor 22539723, 21658600
Q92993 (KAT5) S90 PhosphoSitePlus 21658600
Q96F46 (IL17RA) T780 RLIMS-P+ 26871944
Q96G01-1 (BICD1) S585 HPRD 17139249
Q96G01-1 (BICD1) T597 HPRD 17139249
Q96R06 (SPAG5) T111 PhosphoSitePlus   Signor 18055457
Q96R06 (SPAG5) T937 PhosphoSitePlus   Signor 18055457
Q96R06 (SPAG5) S974 PhosphoSitePlus   Signor 18055457
Q96R06 (SPAG5) T978 PhosphoSitePlus   Signor 18055457
Q96RR4 (CAMKK2) S129 Signor 22778263
Q96RR4 (CAMKK2) S133 Signor 22778263
Q96RR4 (CAMKK2) S137 Signor 22778263
Q99626 (CDX2) S283 PhosphoSitePlus 16027724
Q9BYG3 (NIFK) S230 PhosphoSitePlus 16244663
Q9BYG3 (NIFK) T234 PhosphoSitePlus 16244663
Q9H0B6 (KLC2) S608 PhosphoSitePlus 20534517
Q9H0Z9 (RBM38) S195 PhosphoSitePlus   Signor 24142875
Q9HB09 (BCL2L12) S156 PhosphoSitePlus   Signor 22262180
Q9NP62 (GCM1) S322 PhosphoSitePlus 19416964
Q9NQX3 (GPHN) S270 Signor 23408424
Q9NRD5 (PICK1) S342 PhosphoSitePlus 26472923
Q9NRD5 (PICK1) S415 PhosphoSitePlus 26472923
Q9NRR4 (DROSHA) S300 PhosphoSitePlus 21674040
Q9NRR4 (DROSHA) S302 PhosphoSitePlus 21674040
Q9NS23-2 (RASSF1) S175 PhosphoSitePlus 20069457
Q9NS23-2 (RASSF1) S178 PhosphoSitePlus 20069457
Q9NS23-2 (RASSF1) S179 PhosphoSitePlus 20069457
Q9NYF8 (BCLAF1) S531 PhosphoSitePlus 17570479
Q9UBN7 (HDAC6) S22 RLIMS-P+ 20520769
Q9UKA4 (AKAP11) T1136 PhosphoSitePlus 26088133
Q9UKA4 (AKAP11) T1140 PhosphoSitePlus 26088133
Q9UKT5 (FBXO4) S12 PhosphoSitePlus   Signor 18598945, 21242966
Q9UMX1 (SUFU) S342 PhosphoSitePlus 21317289
Q9UQB3 (CTNND2) T1056 neXtProt 19706605
Q9Y6H5 (SNCAIP) S556 PhosphoSitePlus   Signor 16174773


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047635 (hGSK3B/Phos:2) pS9 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S15 P49841 (GSK3B) unknown eFIP 22911714
Phosphorylation P49841 (GSK3B) S9 P12236 (SLC25A6) unknown eFIP 28591721
Phosphorylation P49841 (GSK3B) S9 Q9UK76 (JPT1) unknown eFIP 25169422
Phosphorylation P49841 (GSK3B) S9 P61978 (HNRNPK) increased_association eFIP 26638989
Phosphorylation P49841 (GSK3B) S9 P10415 (BCL2) decreased_association eFIP 23514933
Phosphorylation P49841 (GSK3B) S9 Q9NRI5 (DISC1) unknown eFIP 30285728


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035774 (hCTNNB1/iso:1/Phos:4) increased Interaction PR:P49841 (hGSK3B) PRO 12051714, 20419129, 23606879


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 F9 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S25 N25 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S25 C25 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y117 * Biomuta DOID:3571 / liver cancer [ icgc ]
S215 L215 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ tcga ]
Y216 C216 Biomuta DOID:1324 / lung cancer [ tcga ]
S389 P389 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]