iPTMnet Report for P49840 (GSK3A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49840 / GSK3A_HUMAN
Protein Name Glycogen synthase kinase-3 alpha
Gene Name Name: GSK3A
Organism Homo sapiens (Human)

PRO ID PR:P49840
DAG View
PRO Name glycogen synthase kinase-3 alpha (human)
Definition A glycogen synthase kinase-3 alpha that is encoded in the genome of human.
Short Label hGSK3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49840 (GSK3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 19369195
S2 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
S7 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
R16 Methylation PhosphoSitePlus
T19 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 20068231
S20 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
S21 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16543730, 12054501, 11583116, ...24035907, 17192257, 15178423, 18691976, 11563975, 11035810, 19413330, 19507191, 23142783, 17148450, 11577096, 16987514, 11884598, 18701488, 11749387, 11340086, 19911376, 20841359, 16803855
S21 Phosphorylation O00141 (SGK1) HPRD 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
S21 Phosphorylation O94806 (PRKD3) HPRD   neXtProt 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
S21 Phosphorylation P05129 (PRKCG) HPRD   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
S21 Phosphorylation P05771 (PRKCB) HPRD   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
S21 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
S21 Phosphorylation P17612 (PRKACA) HPRD   neXtProt   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
S21 Phosphorylation P24723 (PRKCH) PhosphoSitePlus   Signor 11884598
S21 Phosphorylation P31749 (AKT1) HPRD   neXtProt   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11563975, 11340086, 11035810, 11577096
S21 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus   Signor 11583116
S21 Phosphorylation Q05655 (PRKCD) HPRD   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
S21 Phosphorylation Q13554 (CAMK2B) Signor 20841359
S21 Phosphorylation Q14164 (IKBKE) PhosphoSitePlus 23142783
S21 Phosphorylation Q96BR1 (SGK3) HPRD   Signor 11884598, 16543730, 12054501, ...18691976, 11749387, 19413330, 11035810
S39 Phosphorylation HPRD   PhosphoSitePlus 18691976
S41 Phosphorylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S63 Phosphorylation HPRD   PhosphoSitePlus 18691976
S64 Phosphorylation HPRD 18691976
S72 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
S77 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19369195, 18691976
T84 Phosphorylation HPRD 18691976
S97 Phosphorylation PhosphoSitePlus   UniProt 19369195
T101 Phosphorylation HPRD 18691976
T106 O-Glycosylation GlyGen 32119511, 34019948, 34725712, ...35138101, 28657654
K123 Acetylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
S278 Phosphorylation HPRD   PhosphoSitePlus 17192257
S278 Phosphorylation P49840 (GSK3A) HPRD 17192257
Y279 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19413330, 17389395, 18088087, ...18701488, 18767875, 19664994, 17192257, 18452278, 18083107, 17148450, 18669648, 24521712, 15592455, 20080974, 14570592, 19415658
Y279 Phosphorylation P49840 (GSK3A) HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 18701488, 17389395, ...18088087, 18767875, 19664994, 18452278, 15592455, 20080974, 14570592, 19415658
S282 Phosphorylation HPRD   PhosphoSitePlus 19413330
Y284 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
C398 Methylation IEDB 31844290
T478 Phosphorylation HPRD 18691976
T480 Phosphorylation HPRD   PhosphoSitePlus 18691976
S482 Phosphorylation HPRD 18691976
S483 O-Glycosylation GlyGen 32938750


P49840 (GSK3A) as PTM Enzyme



Substrate Site Score Source PMID
O15084 (ANKRD28) S1007 PhosphoSitePlus 17023142
O75030-9 (MITF) S298 PhosphoSitePlus 10587587
O75030 (MITF) S405 Signor 10587587
O75581 (LRP6) S1544 PhosphoSitePlus 21406690
P05412 (JUN) T239 Signor 1846781
P05412 (JUN) S243 Signor 1846781
P05412 (JUN) S249 Signor 1846781
P10636-7 (MAPT) T152 neXtProt 17229088
P10636-7 (MAPT) S173 neXtProt 17229088
P10636-7 (MAPT) T176 neXtProt 17229088
P10636-8 (MAPT) T231 PhosphoSitePlus 9735171, 17045592
P10636-2 (MAPT) S235 HPRD   PhosphoSitePlus 9735171, 7931292, 7706316
P10636-8 (MAPT) S262 PhosphoSitePlus 17045592
P10636-6 (MAPT) S266 HPRD 7931292, 7706316
P10636-8 (MAPT) S324 HPRD 7931292, 7706316
P10636-8 (MAPT) S396 PhosphoSitePlus 20080974
P10636-8 (MAPT) S404 PhosphoSitePlus 20080974
P10636 (MAPT) S579 Signor 9771888
P10636 (MAPT) S641 Signor 7706316
P10636 (MAPT) S713 neXtProt 20080974, 17229088
P10636 (MAPT) S721 neXtProt 20080974, 17229088
P13051 (UNG) T60 Signor 27875297
P13051 (UNG) S64 Signor 27875297
P13807 (GYS1) S641 Signor 14593110
P17812 (CTPS1) S571 PhosphoSitePlus 17681942
P20749 (BCL3) S402 PhosphoSitePlus 15469820
P20749 (BCL3) S406 PhosphoSitePlus 15469820
P22415 (USF1) T153 PhosphoSitePlus 21873430
P22415 (USF1) S186 PhosphoSitePlus 21873430
P23246 (SFPQ) T687 Signor 20932480
P24864 (CCNE1) T395 PhosphoSitePlus 14536078
P31749 (AKT1) T312 PhosphoSitePlus 23142783
P35222 (CTNNB1) S33 PhosphoSitePlus 11955436
P35222 (CTNNB1) S37 PhosphoSitePlus 11955436
P35222 (CTNNB1) T41 PhosphoSitePlus 11955436
P49840 (GSK3A) S278 HPRD 17192257
P49840 (GSK3A) Y279 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 18701488, 17389395, ...18088087, 18767875, 19664994, 18452278, 15592455, 20080974, 14570592, 19415658
Q00613-1 (HSF1) S303 HPRD 19413330, 18212344, 19664994, ...19651622, 18669648, 12665592, 20166139, 20068231
Q03060-16 (CREM) S83 HPRD 8404858
Q05397 (PTK2) S722 neXtProt 15975092
Q07817 (BCL2L1) S62 PhosphoSitePlus 22617334
Q07820 (MCL1) S159 HPRD   Signor 16543145
Q07820-1 (MCL1) T163 HPRD 16543145
Q13144 (EIF2B5) S540 HPRD   Signor 11500362, 9468292
Q13144 (EIF2B5) S544 HPRD 19413330, 18691976, 18088087, ...15302935, 19664994, 19007248, 18452278, 19651622, 18669648, 18707149, 20166139, 11500362, 20068231
Q13563 (PKD2) S76 PhosphoSitePlus   Signor 16551655
Q16555 (DPYSL2) S518 PhosphoSitePlus 17902168
Q16584 (MAP3K11) S789 PhosphoSitePlus 17711861
Q16584 (MAP3K11) S793 PhosphoSitePlus 17711861
Q2M1Z3 (ARHGAP31) T789 neXtProt 17158447
Q6R327 (RICTOR) T1695 PhosphoSitePlus 25897075
Q8NHW3 (MAFA) S49 Signor 18042454
Q8NHW3 (MAFA) T53 Signor 18042454
Q8NHW3 (MAFA) T57 Signor 18042454
Q8NHW3 (MAFA) S61 Signor 18042454
Q92597 (NDRG1) S342 PhosphoSitePlus 15461589
Q92597 (NDRG1) S352 PhosphoSitePlus 15461589
Q92597 (NDRG1) S362 PhosphoSitePlus 15461589
Q92908 (GATA6) S37 Signor 27273097
Q96RR4 (CAMKK2) S129 Signor 22778263
Q96RR4 (CAMKK2) S133 Signor 22778263
Q96RR4 (CAMKK2) S137 Signor 22778263
Q9BYG3 (NIFK) S230 PhosphoSitePlus 16244663
Q9BYG3 (NIFK) T234 PhosphoSitePlus 16244663
Q9NZ72 (STMN3) S60 PhosphoSitePlus 22577147
Q9Y4H4 (GPSM3) S35 Signor 22843681


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K166 T166 Biomuta DOID:363 / uterine cancer [ icgc ]
Y177 C177 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K246 E246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y284 H284 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y285 C285 Biomuta DOID:263 / kidney cancer [ cosmic ]
K366 T366 Biomuta DOID:3571 / liver cancer [ cosmic ]
K366 N366 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C398 Y398 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]