Protein Information

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UniProt AC / UniProt ID P49815 / TSC2_HUMAN
Protein Name Tuberin
Gene Name Name: TSC2
Synonyms:TSC4;
Organism Homo sapiens (Human)

PRO ID PR:P49815
DAG View
PRO Name tuberin (human)
Definition A tuberin that is encoded in the genome of human.
Short Label hTSC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49815 (TSC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S540 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18308511, 15851026
K658 Ubiquitination PhosphoSitePlus
S664 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17671177, 26345496, 21300751, ...15851026, 18308511, 24705102, 26844273, 27551480
R751 Methylation PhosphoSitePlus
T760 Phosphorylation PhosphoSitePlus
K914 Ubiquitination PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
T927 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K930 Ubiquitination PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
T938 Phosphorylation PhosphoSitePlus
S939 Phosphorylation P31749 (AKT1) , P31751 (AKT2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24612393, 28053105, 26827808, ...12438239, 27451907, 19593385, 12150915, 18308511, 27481935, 19505958, 12172553, 16636147, 15342917, 27557496, 18451215, 20169078, 24316235
S946 Phosphorylation PhosphoSitePlus
S960 Phosphorylation PhosphoSitePlus
K967 Methylation PhosphoSitePlus
S981 Phosphorylation P31749 (AKT1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16636147, 23186163, 15342917, ...18669648, 20169078
S999 Phosphorylation PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus
S1096 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1097 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
K1111 Ubiquitination PhosphoSitePlus
R1122 Methylation PhosphoSitePlus
S1130 Phosphorylation PRO   PhosphoSitePlus
S1132 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S1155 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
Y1186 Phosphorylation PhosphoSitePlus
Y1250 Phosphorylation PhosphoSitePlus
K1251 Ubiquitination PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
S1254 Phosphorylation P49137 (MAPKAPK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26844273, 26345496, 12582162
S1269 Phosphorylation PhosphoSitePlus
S1304 Phosphorylation PhosphoSitePlus
T1330 Phosphorylation A0A0A0N0L1 (AMPK alpha 2) UniProt 14651849
S1334 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1337 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1340 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1346 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
R1355 Methylation PhosphoSitePlus
S1364 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1365 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
S1375 Phosphorylation PhosphoSitePlus
S1379 Phosphorylation PhosphoSitePlus
S1383 Phosphorylation PhosphoSitePlus
S1385 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1386 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1387 Phosphorylation P54646 (PRKAA2) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16959574, 27557496, 15963462, ...22113203, 18669648
S1388 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1393 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1411 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...24275569
S1418 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15963462
S1420 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 15963462
T1422 Phosphorylation PhosphoSitePlus
S1427 Phosphorylation PhosphoSitePlus
S1448 Phosphorylation A0A0A0N0L1 (AMPK alpha 2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 14651849
S1449 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1452 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1454 Phosphorylation PhosphoSitePlus
Y1461 Phosphorylation PhosphoSitePlus
T1462 Phosphorylation P31749 (AKT1) , P31751 (AKT2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24612393, 26345496, 15757502, ...19593385, 12150915, 18308511, 27481935, 22539739, 21252047, 22333157, 20038548, 15342917, 27557496, 21283628, 12172553, 19505958, 26844273, 20169078, 19690332
S1466 Phosphorylation PhosphoSitePlus
S1469 Phosphorylation PhosphoSitePlus
Y1571 Phosphorylation phospho.ELM   PhosphoSitePlus 11290735
S1647 Phosphorylation PhosphoSitePlus
Y1650 Phosphorylation PhosphoSitePlus
S1653 Phosphorylation PhosphoSitePlus
S1684 Phosphorylation PhosphoSitePlus
T1697 Phosphorylation PhosphoSitePlus
S1704 Phosphorylation PhosphoSitePlus
S1730 Phosphorylation PhosphoSitePlus
Y1736 Phosphorylation PhosphoSitePlus
Y1760 Phosphorylation PhosphoSitePlus
S1761 Phosphorylation PhosphoSitePlus
S1764 Phosphorylation PhosphoSitePlus
T1780 Phosphorylation PhosphoSitePlus
Y1788 Phosphorylation PhosphoSitePlus
S1798 Phosphorylation Q15418 (RPS6KA1) , P51812 (RPS6KA3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15757502, 18308511, 15342917, ...26844273, 19690332, 20068231
S1799 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S540 Phosphorylation P28482 (MAPK1) HPRD 15851026
Y602 Phosphorylation HPRD 20068231
S608 Phosphorylation HPRD 20068231
S664 Phosphorylation P28482 (MAPK1) HPRD 15851026
T927 Phosphorylation HPRD 18669648
S939 Phosphorylation P31749 (AKT1) HPRD 15342917, 16636147, 12438239, ...18707149
S981 Phosphorylation HPRD 18669648
S1094 Phosphorylation HPRD 18691976
S1096 Phosphorylation HPRD 18669648
S1097 Phosphorylation HPRD 18669648
S1130 Phosphorylation HPRD 20068231
S1132 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18212344, 20068231
S1155 Phosphorylation HPRD 18691976, 18669648
S1254 Phosphorylation P49137 (MAPKAPK2) HPRD 12582162
S1259 Phosphorylation HPRD 20068231
S1334 Phosphorylation HPRD 18669648
S1337 Phosphorylation HPRD 18669648
S1338 Phosphorylation HPRD 18669648
S1341 Phosphorylation HPRD 18669648
S1346 Phosphorylation HPRD 19651622, 20068231
S1364 Phosphorylation HPRD 18767875
S1385 Phosphorylation HPRD 18691976, 18669648, 20068231
S1386 Phosphorylation HPRD 18669648
S1387 Phosphorylation HPRD 19413330, 18669648, 15963462
S1388 Phosphorylation HPRD 19413330, 18669648
T1393 Phosphorylation HPRD 18669648
S1411 Phosphorylation HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
S1418 Phosphorylation HPRD 18691976, 15963462
S1420 Phosphorylation HPRD 19413330, 18669648, 15963462
S1447 Phosphorylation HPRD 17081983, 20068231
S1448 Phosphorylation HPRD 18691976, 18669648, 17081983
S1449 Phosphorylation HPRD 18669648
S1452 Phosphorylation HPRD 18669648, 20068231
T1462 Phosphorylation P31749 (AKT1) HPRD 12150915, 15342917, 19664994
Y1571 Phosphorylation HPRD 11290735
S1798 Phosphorylation Q15418 (RPS6KA1) HPRD 15342917, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S932 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S1086 Phosphorylation PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus
S1320 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation PhosphoSitePlus
T1418 Phosphorylation PhosphoSitePlus
S1754 Phosphorylation PhosphoSitePlus
S1755 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1130 Phosphorylation PhosphoSitePlus
S1132 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
S1254 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus
S1281 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation PhosphoSitePlus
S1362 Phosphorylation PhosphoSitePlus
S1776 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y602 Phosphorylation HPRD 20068231
S608 Phosphorylation HPRD 20068231
T927 Phosphorylation HPRD 18669648
S939 Phosphorylation HPRD 16636147, 18707149
S1050 Phosphorylation HPRD 18691976
S1052 Phosphorylation HPRD 18669648
S1053 Phosphorylation HPRD 18669648
S1086 Phosphorylation HPRD 20068231
S1088 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18212344, 20068231
S1111 Phosphorylation HPRD 18691976, 18669648
S1215 Phosphorylation HPRD 20068231
S1267 Phosphorylation HPRD 18669648
S1270 Phosphorylation HPRD 18669648
S1271 Phosphorylation HPRD 18669648
S1274 Phosphorylation HPRD 18669648
S1279 Phosphorylation HPRD 19651622, 20068231
S1297 Phosphorylation HPRD 18767875
S1318 Phosphorylation HPRD 18691976, 18669648, 20068231
S1319 Phosphorylation HPRD 18669648
S1320 Phosphorylation HPRD 19413330, 18669648, 15963462
S1321 Phosphorylation HPRD 19413330, 18669648
T1326 Phosphorylation HPRD 18669648
S1344 Phosphorylation HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
S1351 Phosphorylation HPRD 18691976, 15963462
S1353 Phosphorylation HPRD 19413330, 18669648, 15963462
S1380 Phosphorylation HPRD 17081983, 20068231
S1381 Phosphorylation HPRD 18691976, 18669648, 17081983
S1382 Phosphorylation HPRD 18669648
S1385 Phosphorylation HPRD 18669648, 20068231
T1395 Phosphorylation HPRD 19664994
S1731 Phosphorylation HPRD 17081983, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049554 (hTSC2/Phos:2) pS1387 PRO
PR:000049555 (hTSC2/Phos:3) pS939,pT1462 PRO
PR:000049556 (hTSC2/Phos:4) pS939,pS1130,pT1462 PRO