Protein Information

Cytoscape View


UniProt AC / UniProt ID P49796 / RGS3_HUMAN
Protein Name Regulator of G-protein signaling 3
Gene Name Name: RGS3
Organism Homo sapiens (Human)

PRO ID PR:P49796
DAG View
PRO Name regulator of G-protein signaling 3 (human)
Definition A regulator of G-protein signaling 3 that is encoded in the genome of human.
Short Label hRGS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49796 (RGS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K189 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
R448 Methylation PhosphoSitePlus   UniProt 24129315
Y468 Phosphorylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
Y503 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus   UniProt 23186163
S777 Phosphorylation PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
T808 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
T921 Phosphorylation PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus
T941 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus   UniProt 23186163
S946 Phosphorylation PhosphoSitePlus
S958 Phosphorylation PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
S992 Phosphorylation PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
T1011 Phosphorylation PhosphoSitePlus
K1023 Acetylation PhosphoSitePlus
K1029 Acetylation PhosphoSitePlus
K1032 Acetylation PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
K1117 Acetylation PhosphoSitePlus
K1121 Acetylation PhosphoSitePlus
K1124 Acetylation PhosphoSitePlus
K1136 Acetylation PhosphoSitePlus
K1149 Ubiquitination PhosphoSitePlus
K1165 Ubiquitination PhosphoSitePlus
S1195 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S496 Phosphorylation HPRD 18452278
S943 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S215 Phosphorylation HPRD 18452278
T660 Phosphorylation PhosphoSitePlus
S662 Phosphorylation HPRD   PhosphoSitePlus 19651622
S665 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S384 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
K139 Acetylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K145 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R448 L448 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R448 H448 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3953 / adrenal gland cancer [ tcga ]
S777 L777 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S806 Y806 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
T808 A808 Biomuta DOID:1909 / melanoma [ cosmic ]
S823 F823 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
S946 I946 Biomuta DOID:3571 / liver cancer [ icgc ]
K1032 N1032 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K1136 N1136 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K1165 N1165 Biomuta DOID:363 / uterine cancer [ tcga ]