iPTMnet Report for P49770 (EIF2B2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49770 / EI2BB_HUMAN
Protein Name Translation initiation factor eIF-2B subunit beta
Gene Name Name: EIF2B2
Synonyms:EIF2BB;
Organism Homo sapiens (Human)

PRO ID PR:P49770
DAG View
PRO Name translation initiation factor eIF-2B subunit beta (human)
Definition A translation initiation factor eIF-2B subunit beta that is encoded in the genome of human.
Short Label hEIF2B2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49770 (EIF2B2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
C198 Methylation IEDB 31844290
K231 Ubiquitination PhosphoSitePlus
T236 Phosphorylation HPRD   PhosphoSitePlus 20068231
K237 Ubiquitination PhosphoSitePlus
T238 Phosphorylation HPRD   PhosphoSitePlus 20068231
K273 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S100 N100 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C198 Y198 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]