iPTMnet Report for P49768 (PSEN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49768 / PSN1_HUMAN
Protein Name Presenilin-1
Gene Name Name: PSEN1
Synonyms:AD3,PS1,PSNL1;
Organism Homo sapiens (Human)

PRO ID PR:P49768
DAG View
PRO Name presenilin-1 (human)
Definition A presenilin-1 that is encoded in the genome of human.
Short Label hPSEN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49768 (PSEN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983
S51 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
S310 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14576165
S313 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
Y315 Phosphorylation PhosphoSitePlus
S319 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18667537
S319 Phosphorylation P45984 (MAPK9) neXtProt   PhosphoSitePlus   Signor 18667537
T320 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18667537
T320 Phosphorylation P45984 (MAPK9) neXtProt   PhosphoSitePlus   Signor 18667537
S324 Phosphorylation PhosphoSitePlus
S346 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14576165
S346 Phosphorylation P05129 (PRKCG) Signor 14576165
S346 Phosphorylation P05771 (PRKCB) Signor 14576165
S346 Phosphorylation P17252 (PRKCA) Signor 14576165
S346 Phosphorylation Q05513 (PRKCZ) Signor 14576165
S353 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 21238544, 22443192, 17389597, ...17360711, 11104755
S353 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 11104755, 17389597, 17360711
T354 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20456003, 12056836
T354 Phosphorylation Q00535 (CDK5) phospho.ELM   PhosphoSitePlus   Signor 12056836
T354 Phosphorylation Q13627 (DYRK1A) neXtProt 20456003
S357 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 11104755, 17389597, 22443192, ...17360711
S357 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 11104755, 17389597, 17360711
S365 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S366 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S367 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...28533369, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation HPRD 18691976, 18578522, 17081983, ...20068231
S51 Phosphorylation HPRD 20068231
S59 Phosphorylation HPRD 20068231
S310 Phosphorylation HPRD 14576165
S310 Phosphorylation P17612 (PRKACA) HPRD 14576165
S346 Phosphorylation HPRD 14576165
S346 Phosphorylation Q05513 (PRKCZ) HPRD 14576165
S353 Phosphorylation HPRD 11104755
S353 Phosphorylation P49841 (GSK3B) HPRD 11104755
T354 Phosphorylation HPRD 12056836
T354 Phosphorylation Q00535 (CDK5) HPRD 12056836
S357 Phosphorylation HPRD 11104755
S357 Phosphorylation P49841 (GSK3B) HPRD 11104755
S365 Phosphorylation HPRD 18691976, 17081983, 20058876, ...19651622, 18669648, 20068231
S366 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S367 Phosphorylation HPRD 18691976, 18578522, 20058876, ...19651622, 18669648, 15345747, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 18691976, 18578522, 17081983, ...20068231
S47 Phosphorylation HPRD 20068231
S55 Phosphorylation HPRD 20068231
T350 Phosphorylation HPRD 17081983
S361 Phosphorylation HPRD 18691976, 17081983, 20058876, ...19651622, 18669648, 20068231
S362 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S363 Phosphorylation HPRD 18691976, 18578522, 17081983, ...20058876, 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S363 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 P47 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S51 P51 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K109 N109 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y256 C256 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S313 F313 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y315 C315 Biomuta DOID:263 / kidney cancer [ cosmic ]
S346 N346 Biomuta DOID:4362 / cervical cancer [ icgc ]
S361 F361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S363 T363 Biomuta DOID:1319 / brain cancer [ cosmic ]
S365 F365 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S367 T367 Biomuta DOID:1319 / brain cancer [ cosmic ]