iPTMnet Report for P49760 (CLK2)
Protein Information
| UniProt AC / UniProt ID | P49760 / CLK2_HUMAN |
| Protein Name | Dual specificity protein kinase CLK2 |
| Gene Name | Name: CLK2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P49760 |
| PRO Name | dual specificity protein kinase CLK2 (human) |
| Definition | A dual specificity protein kinase CLK2 that is encoded in the genome of human. |
| Short Label | hCLK2 |
| Category | organism-gene |
DAG ViewP49760 (CLK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y7 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S9 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S17 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S34 | Phosphorylation | P31749 (AKT1) | score3 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 20682768 | |
| S50 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y51 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S57 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S58 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S64 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y82 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S83 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y91 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y95 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S98 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 29769258, 23186163 | ||
| Y101 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T127 | Phosphorylation | P31749 (AKT1) | score3 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 20682768 | |
| S142 | Phosphorylation | P49760 (CLK2) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 18691976, 23186163, 19369195, ... | |
| Y153 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S167 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T344 | Phosphorylation | P31751 (AKT2) | score2 | neXtProt | 20074525 | |
| S402 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y430 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T469 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S493 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S498 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S98 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S106 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S50 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y51 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y82 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y95 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S98 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S133 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S135 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S136 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S141 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 | ||
| S492 | Phosphorylation | score0 | HPRD | 18691976 |
P49760 (CLK2) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P18031 (PTPN1) | S50 | score4 | HPRD neXtProt PhosphoSitePlus Signor | 18691976, 11579209, 10480872 | |
| P18031 (PTPN1) | S242 | score3 | HPRD neXtProt PhosphoSitePlus | 10480872 | |
| P18031 (PTPN1) | S243 | score3 | HPRD neXtProt PhosphoSitePlus | 10480872 | |
| P48730 (CSNK1D) | S370 | score2 | neXtProt | 17594292 | |
| P49760 (CLK2) | S142 | score4 | neXtProt Signor UniProt | 18669648, 20682768, 9852100 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y7 | F7 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| S55 | F55 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
| S83 | R83 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y95 | C95 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S98 | F98 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S133 | L133 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| S135 | N135 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S167 | G167 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S402 | F402 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y430 | C430 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] | |
| T469 | A469 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| T469 | S469 | Biomuta | [ cosmic ] |
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