Protein Information

Cytoscape View


UniProt AC / UniProt ID P49759 / CLK1_HUMAN
Protein Name Dual specificity protein kinase CLK1
Gene Name Name: CLK1
Synonyms:CLK;
Organism Homo sapiens (Human)

PRO ID PR:P49759
DAG View
PRO Name dual specificity protein kinase CLK1 (human)
Definition A dual specificity protein kinase CLK1 that is encoded in the genome of human.
Short Label hCLK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49759 (CLK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K15 Ubiquitination PhosphoSitePlus
K21 Sumoylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
K50 Sumoylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus   UniProt 18691976
K65 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
T138 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19369195, 18669648
S158 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K191 Sumoylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
T302 O-Glycosylation GlyGen 29351928
Y305 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K322 Sumoylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
S337 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T338 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S341 Phosphorylation PhosphoSitePlus
T342 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation HPRD 18691976
S61 Phosphorylation HPRD 18691976
T138 Phosphorylation HPRD 18691976, 18669648, 17081983
S140 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18452278
S328 Phosphorylation HPRD 18691976
T330 Phosphorylation HPRD 18691976
Y331 Phosphorylation HPRD 18691976
S337 Phosphorylation HPRD 18691976, 18669648
T338 Phosphorylation HPRD 18669648
S341 Phosphorylation HPRD 18691976, 20068231
T342 Phosphorylation HPRD 18691976
Y345 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus


P49759 (CLK1) as PTM Enzyme



Substrate Site Score Source PMID
P00519 (ABL1) T735 neXtProt   PhosphoSitePlus   Signor 18794806
P18031 (PTPN1) S50 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18691976, 11579209, 10480872
P18031 (PTPN1) S242 HPRD   neXtProt   PhosphoSitePlus 10480872
P18031 (PTPN1) S243 HPRD   neXtProt   PhosphoSitePlus 10480872
Q96I25 (RBM17) S48 neXtProt   PhosphoSitePlus 23519612
Q96I25 (RBM17) S62 neXtProt   PhosphoSitePlus 23519612
Q96I25 (RBM17) S202 neXtProt   PhosphoSitePlus 23519612
Q96I25 (RBM17) S204 neXtProt   PhosphoSitePlus 23519612
Q96I25 (RBM17) S222 neXtProt   PhosphoSitePlus 23519612
Q96I25 (RBM17) S266 neXtProt   PhosphoSitePlus 23519612
Q96I25 (RBM17) S288 neXtProt   PhosphoSitePlus 23519612
Q96I25 (RBM17) S291 neXtProt   PhosphoSitePlus 23519612


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P18031 (PTPN1) S50 P49759 (CLK1) unknown eFIP 10480872


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 T24 Biomuta DOID:3571 / liver cancer [ tcga ]
S36 N36 Biomuta DOID:2531 / hematologic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S102 R102 Biomuta DOID:3571 / liver cancer [ icgc ]
S104 A104 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T123 I123 Biomuta DOID:363 / uterine cancer [ tcga ]
T138 A138 Biomuta DOID:1793 / pancreatic cancer [ tcga ]