iPTMnet Report for P49757 (NUMB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49757 / NUMB_HUMAN
Protein Name Protein numb homolog
Gene Name Name: NUMB
Synonyms:C14orf41;
Organism Homo sapiens (Human)

PRO ID PR:P49757
DAG View
PRO Name protein numb homolog (human)
Definition A protein numb that is encoded in the genome of human.
Short Label hNUMB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49757 (NUMB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus   RLIMS-P 21775625
K12 Ubiquitination PhosphoSitePlus
Y15 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
R53 Methylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
T102 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18657069
T102 Phosphorylation Q2M2I8 (AAK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18657069
R121 Methylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
S194 Phosphorylation IEDB   PhosphoSitePlus   UniProt 27920218, 23186163
S238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S241 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T246 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
S276 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17022975, 17609107
S276 Phosphorylation Q14012 (CAMK1) neXtProt   Signor 17022975
R278 Methylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus   RLIMS-P+ 25403733
S288 Phosphorylation Q00535 (CDK5) RLIMS-P+ 25403733
S295 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 17022975, 17609107
S295 Phosphorylation Q14012 (CAMK1) neXtProt 17022975
S361 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus   UniProt 23186163
T436 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S438 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569
S448 Phosphorylation PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
T631 Phosphorylation PhosphoSitePlus
S634 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD   IntAct 17203073
S7 Phosphorylation Q05513 (PRKCZ) HPRD 17203073
S20 Phosphorylation HPRD 20068231
S240 Phosphorylation HPRD 18669648
S241 Phosphorylation HPRD 18669648, 20068231
S244 Phosphorylation HPRD 18669648, 20068231
S276 Phosphorylation HPRD 17081983
S295 Phosphorylation HPRD 18767875, 17203073
S295 Phosphorylation Q05513 (PRKCZ) HPRD 18767875, 17203073
T436 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S438 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231, 18452278
S634 Phosphorylation HPRD 20166139, 18669648, 19664994, ...16964243, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 17203073
S7 Phosphorylation Q05513 (PRKCZ) HPRD 17203073
S20 Phosphorylation HPRD 20068231
S238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation HPRD 18669648
S241 Phosphorylation HPRD 18669648, 20068231
S244 Phosphorylation HPRD 18669648, 20068231
S276 Phosphorylation HPRD 17081983
S288 Phosphorylation PhosphoSitePlus
S295 Phosphorylation HPRD 18767875, 17203073
S295 Phosphorylation Q05513 (PRKCZ) HPRD 18767875, 17203073
S361 Phosphorylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
T388 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S390 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231, 18452278
S586 Phosphorylation HPRD 20166139, 18669648, 19664994, ...16964243, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S20 Phosphorylation HPRD 20068231
K63 Methylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S229 Phosphorylation HPRD 18669648
S230 Phosphorylation HPRD 18669648, 20068231
S233 Phosphorylation HPRD 18669648, 20068231
S265 Phosphorylation HPRD   PhosphoSitePlus 17081983
S277 Phosphorylation PhosphoSitePlus
S284 Phosphorylation HPRD   PhosphoSitePlus 18767875, 17081983
T425 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 17081983, ...20068231
S427 Phosphorylation HPRD   PhosphoSitePlus 17081983, 18767875, 18452278, ...19651622, 20068231
T550 Phosphorylation PhosphoSitePlus
S623 Phosphorylation HPRD 20166139, 18669648, 19664994, ...16964243, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 20068231
S229 Phosphorylation HPRD 18669648
S230 Phosphorylation HPRD 18669648, 20068231
S233 Phosphorylation HPRD 18669648, 20068231
S265 Phosphorylation HPRD 17081983
S284 Phosphorylation HPRD 18767875, 17081983
T377 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S379 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231, 18452278
S575 Phosphorylation HPRD 20166139, 18669648, 19664994, ...16964243, 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 N7 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K73 Q73 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K73 R73 Biomuta DOID:1324 / lung cancer [ cosmic ]
S194 L194 Biomuta DOID:363 / uterine cancer [ icgc ]
S227 F227 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S238 F238 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R278 P278 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K286 N286 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]