iPTMnet Report for P49755 (TMED10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49755 / TMEDA_HUMAN
Protein Name Transmembrane emp24 domain-containing protein 10 precursor
Gene Name Name: TMED10
Synonyms:TMP21;
Organism Homo sapiens (Human)

PRO ID PR:P49755
DAG View
PRO Name transmembrane emp24 domain-containing protein 10 (human)
Definition A transmembrane emp24 domain-containing protein 10 that is encoded in the genome of human.
Short Label hTMED10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49755 (TMED10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
C43 Methylation IEDB 31844290
K50 Ubiquitination PhosphoSitePlus
T55 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380, ...22661428
Y58 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
T77 O-Glycosylation GlyGen   PhosphoSitePlus 25813380
Y85 Phosphorylation PhosphoSitePlus
S86 O-Glycosylation GlyGen 25813380
K87 Ubiquitination PhosphoSitePlus
T91 O-Glycosylation GlyGen 25813380
K92 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
R152 Methylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S40 C40 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K133 N133 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y135 F135 Biomuta DOID:1324 / lung cancer [ cosmic ]
K143 R143 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R152 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R152 Q152 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K169 E169 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T184 S184 Biomuta DOID:1324 / lung cancer [ cosmic ]