iPTMnet Report for P49753 (ACOT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49753 / ACOT2_HUMAN
Protein Name Acyl-coenzyme A thioesterase 2, mitochondrial precursor
Gene Name Name: ACOT2
Synonyms:PTE2,PTE2A;
Organism Homo sapiens (Human)

PRO ID PR:P49753
DAG View
PRO Name acyl-coenzyme A thioesterase 2, mitochondrial (human)
Definition An acyl-coenzyme A thioesterase 2, mitochondrial that is encoded in the genome of human.
Short Label hACOT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49753 (ACOT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
R86 Methylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K462 Acetylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 Y24 Biomuta DOID:363 / uterine cancer [ icgc ]
R86 C86 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R86 H86 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T118 I118 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S294 F294 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]