iPTMnet Report for P49736 (MCM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49736 / MCM2_HUMAN
Protein Name DNA replication licensing factor MCM2
Gene Name Name: MCM2
Synonyms:BM28,CCNL1,CDCL1,KIAA0030;
Organism Homo sapiens (Human)

PRO ID PR:P49736
DAG View
PRO Name DNA replication licensing factor MCM2 (human)
Definition A DNA replication licensing factor MCM2 that is encoded in the genome of human.
Short Label hMCM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49736 (MCM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 20068231
S4 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19647517, 16864800
S4 Phosphorylation O00311 (CDC7) PhosphoSitePlus 19647517
S4 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16864800
S5 Phosphorylation HPRD   PhosphoSitePlus   Signor 19413330, 19647517, 16864800
S5 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 19647517
S5 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16864800
S7 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19647517, 16864800
S7 Phosphorylation O00311 (CDC7) PhosphoSitePlus 19647517
S7 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16864800
T9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S13 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 21406692, 23186163, ...17081983, 18847512, 16446360, 19651622, 24275569, 20068231
S13 Phosphorylation O00311 (CDC7) Signor 16446360
S13 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus   Signor 16446360, 18847512
S13 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16446360
S13 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 16446360
T25 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18669648, 19415658, 20068231
S26 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 16083285, ...23186163, 17081983, 18767875, 19664995, 19651622, 18669648, 20068231
S27 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34725712, 30069701, 34019948, 22967762, 32119511, 28510447, 33465208
S27 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16964243, 15302935, 19664995, ...18707149, 19647517, 21406692, 23186163, 18212344, 19691289, 18452278, 24275569, 19690332, 19413330, 18220336, 18767875, 20058876, 16446360, 19651622, 17081983, 19664994, 16899510, 17322306, 18669648, 19415658, 20068231
S27 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 16446360, 16899510
S27 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus 19647517, 16446360
S27 Phosphorylation P50613 (CDK7) PhosphoSitePlus   Signor 16446360, 16899510
S27 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 16446360
S31 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18286467
S31 Phosphorylation O00311 (CDC7) PhosphoSitePlus 18286467
S32 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T35 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
T39 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 19691289, 18452278, ...19651622, 18669648, 20068231
S40 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 16446360, 23186163, ...17081983, 19664995, 18452278, 19651622, 18669648, 19647517, 17062569, 18286467, 24902048, 19415658, 20068231, 28273463
S40 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 19647517, 16446360, 24902048, ...18286467, 17062569
S40 Phosphorylation P24941 (CDK2) PhosphoSitePlus 16446360
S40 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16446360
S40 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 16446360
S41 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17322306, 21406692, 16899510, ...23186163, 16964243, 18767875, 15302935, 19664995, 18452278, 19651622, 18669648, 16446360, 18707149, 24902048, 19415658, 20068231, 17081983
S41 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 16446360, 24902048, 16899510
S41 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus 16446360
S41 Phosphorylation P50613 (CDK7) PhosphoSitePlus   Signor 16446360, 16899510
S41 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 16446360
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19647517, 16446360, 16899510, ...17081983, 27401717, 18452278, 19864417, 18669648, 17062569, 18286467, 16864800, 20068231, 28273463
S53 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 19864417, 19647517, 16446360, ...18286467, 17062569
S53 Phosphorylation P24941 (CDK2) PhosphoSitePlus 16446360
S53 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16446360, 16864800
S53 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 16446360
T59 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 18669648, ...19690332, 20068231, 16864800
T59 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16864800
Y81 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
T106 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 15302935
S108 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 17525332, 16446360, ...32192191, 18077418, 19664994, 16899510, 18452278, 18669648, 19647517, 15210935, 25249630, 18286467, 24902048, 19690332, 20068231
S108 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 19647517, 16446360, 24902048, ...18286467
S108 Phosphorylation P24941 (CDK2) PhosphoSitePlus 16446360
S108 Phosphorylation P50613 (CDK7) PhosphoSitePlus 16446360
S108 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 16446360
S108 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   Signor 15210935
R126 Methylation PhosphoSitePlus
Y137 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 18669648, ...24275569, 20068231
S139 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19562805, 32192191, 16899510, ...35956952, 18707149, 35524559, 18691976, 21406692, 23186163, 18212344, 20230923, 18452278, 24275569, 19690332, 19413330, 18220336, 18767875, 16446360, 19651622, 16083285, 17081983, 19664994, 19664995, 17322306, 18669648, 20166139, 18286467, 19415658, 20068231, 17924679
S139 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 18286467, 16446360, 16899510
S139 Phosphorylation P24941 (CDK2) PhosphoSitePlus 16446360
S139 Phosphorylation P50613 (CDK7) PhosphoSitePlus   Signor 16446360, 16899510
S139 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 16446360
T158 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus   UniProt 19608861
K216 Ubiquitination PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus 18286467, 20177074
S220 Phosphorylation O00311 (CDC7) PhosphoSitePlus 18286467
S220 Phosphorylation O14965 (AURKA) PhosphoSitePlus 20177074
K224 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
R307 Methylation PhosphoSitePlus
C315 S-Nitrosylation dbSNO 26338901
S381 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
K384 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K450 Sumoylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus
K462 Sumoylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
T465 O-Glycosylation GlyGen 33465208
S466 O-Glycosylation GlyGen 33465208
S468 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34725712, 30069701, 34019948, 22967762, 32119511, 28510447, 33465208
K469 Acetylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus   UniProt 23186163
K492 Sumoylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K510 Acetylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
S566 Phosphorylation HPRD 20068231
K591 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
R623 Methylation PhosphoSitePlus
R677 Methylation PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K742 Acetylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
R751 Methylation PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
S754 Phosphorylation HPRD   PhosphoSitePlus 20068231
T757 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
K868 Ubiquitination PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
K896 Acetylation PhosphoSitePlus
K896 Ubiquitination PhosphoSitePlus