iPTMnet Report for P49711 (CTCF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49711 / CTCF_HUMAN
Protein Name Transcriptional repressor CTCF
Gene Name Name: CTCF
Organism Homo sapiens (Human)

PRO ID PR:P49711
DAG View
PRO Name transcriptional repressor CTCF (human)
Definition A transcriptional repressor CTCF that is encoded in the genome of human.
Short Label hCTCF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49711 (CTCF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K20 Acetylation PhosphoSitePlus
K74 Sumoylation PhosphoSitePlus
C155 Methylation IEDB 31844290
Y197 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28286735, 20068231
T305 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28286735, 20068231
T319 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus   RLIMS-P 28286735
K352 Methylation PhosphoSitePlus
T374 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32128389, 18669648, 28286735
S382 Phosphorylation PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
S402 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32128389, 18669648, 28286735
Y407 Phosphorylation PhosphoSitePlus
Y410 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus   RLIMS-P 28286735
Y462 Phosphorylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus   RLIMS-P 28286735
S526 Phosphorylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
C577 S-Nitrosylation dbSNO 26338901
S604 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 28286735, 18669648
S609 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17081983, 28286735, ...18669648, 20068231
S610 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17081983, 28286735, ...18669648, 20068231
S612 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17081983, 28286735, ...18669648, 20068231
T642 Phosphorylation PhosphoSitePlus
K689 Sumoylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T289 Phosphorylation HPRD 20068231
T317 Phosphorylation HPRD 20068231
T333 Phosphorylation HPRD 20068231
Y343 Phosphorylation HPRD 20068231
T346 Phosphorylation HPRD 20068231
T374 Phosphorylation HPRD 18669648
T400 Phosphorylation HPRD 20068231
S402 Phosphorylation HPRD 18669648, 20068231
Y407 Phosphorylation HPRD 20068231
Y410 Phosphorylation HPRD 20068231
T431 Phosphorylation HPRD 20068231
S450 Phosphorylation HPRD 20068231
S604 Phosphorylation HPRD 18669648
S609 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S610 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S612 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T717 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 R20 Biomuta DOID:1612 / breast cancer [ cosmic ]
C155 R155 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y197 C197 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y197 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S224 F224 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y226 C226 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
T333 I333 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y343 H343 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y343 C343 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T346 S346 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T346 N346 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K352 N352 Biomuta DOID:363 / uterine cancer [ cosmic ]
T374 A374 Biomuta DOID:1324 / lung cancer [ cosmic ]
S402 L402 Biomuta DOID:1612 / breast cancer [ cosmic ]
K429 N429 Biomuta DOID:3571 / liver cancer [ cosmic ]
K449 T449 Biomuta DOID:363 / uterine cancer [ icgc ]
S461 F461 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K487 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K496 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T516 A516 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T518 S518 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S526 N526 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
Y545 C545 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S558 C558 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S604 C604 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
S609 F609 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S610 F610 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
T717 P717 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T717 M717 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]