iPTMnet Report for P49674 (CSNK1E)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49674 / KC1E_HUMAN
Protein Name Casein kinase I isoform epsilon
Gene Name Name: CSNK1E
Organism Homo sapiens (Human)

PRO ID PR:P49674
DAG View
PRO Name casein kinase I isoform epsilon (human)
Definition A casein kinase I isoform epsilon that is encoded in the genome of human.
Short Label hCSNK1E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49674 (CSNK1E) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
T44 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus   RLIMS-P+ 20507565
K45 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K242 Acetylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
R321 Methylation PhosphoSitePlus
S323 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18691976, 10542239
T325 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10542239
T334 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10542239
T337 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10542239
R342 Methylation PhosphoSitePlus
S343 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18220336, 19369195
S350 Phosphorylation HPRD   PhosphoSitePlus 18691976
T351 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19007248
S354 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19007248, 19369195
T362 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 17081983, ...20068231
S363 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 15302935, ...17192257, 18669648, 20068231, 20068230
S368 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10542239
S377 Phosphorylation PhosphoSitePlus
R382 Methylation PhosphoSitePlus
S389 Phosphorylation Q13131 (PRKAA1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18691976, ...18220336, 19007248, 17192257, 17525164, 19690332
S390 Phosphorylation HPRD   PhosphoSitePlus 18691976, 17192257
S391 Phosphorylation HPRD   PhosphoSitePlus 20068231
T394 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S405 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 10542239, 18691976
T407 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18691976, 10542239
S408 Phosphorylation P49674 (CSNK1E) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 10542239, 18691976


P49674 (CSNK1E) as PTM Enzyme



Substrate Site Score Source PMID
O14640 (DVL1) S139 Signor 16965538
O14640 (DVL1) S142 Signor 16965538
O14641 (DVL2) S143 PhosphoSitePlus   Signor 22609948
O14641 (DVL2) T224 PhosphoSitePlus   Signor 22609948
O15055-1 (PER2) S662 HPRD   PhosphoSitePlus 11232563, 9349507, 21324900
O15055 (PER2) S665 HPRD   PhosphoSitePlus 21324900, 17218255
O15055 (PER2) S668 HPRD   PhosphoSitePlus 21324900, 17218255
O15055-1 (PER2) S671 HPRD 17218255
O15055-1 (PER2) S674 HPRD 17218255
O60716 (CTNND1) S268 Signor 3133391
O75581 (LRP6) S1420 PhosphoSitePlus   Signor 16513652
O75581 (LRP6) S1430 Signor 16513652
O75581 (LRP6) S1431 PhosphoSitePlus 16513652
O95863 (SNAI1) S104 PhosphoSitePlus 20305697
O95863 (SNAI1) S107 PhosphoSitePlus 20305697
P12830 (CDH1) S844 PhosphoSitePlus 17353278
P25054-1 (APC) S1279 HPRD   PhosphoSitePlus   Signor 11487578
P25054 (APC) S1392 HPRD   PhosphoSitePlus   Signor 11487578
P25054-1 (APC) S1504 HPRD 15327768
P25054-1 (APC) S1505 HPRD 15327768
P25054-1 (APC) S1507 HPRD 15327768
P25054-1 (APC) S1510 HPRD 15327768
P35222 (CTNNB1) S45 PhosphoSitePlus   Signor 12000790, 12176352
P46937 (YAP1) S400 Signor 23431053, 24715453
P46937 (YAP1) S403 Signor 23431053, 24715453
P49674 (CSNK1E) T44 RLIMS-P+ 20507565
P49674 (CSNK1E) S323 HPRD   PhosphoSitePlus   Signor 18691976, 10542239
P49674 (CSNK1E) T325 HPRD   PhosphoSitePlus   Signor 10542239
P49674 (CSNK1E) T334 HPRD   PhosphoSitePlus   Signor 10542239
P49674 (CSNK1E) T337 HPRD   PhosphoSitePlus   Signor 10542239
P49674 (CSNK1E) S368 HPRD   PhosphoSitePlus   Signor 10542239
P49674 (CSNK1E) S405 HPRD   PhosphoSitePlus   Signor 18691976, 10542239
P49674 (CSNK1E) T407 HPRD   PhosphoSitePlus   Signor 18691976, 10542239
P49674 (CSNK1E) S408 HPRD   PhosphoSitePlus   Signor 18691976, 10542239
P55957 (BID) T59 HPRD   Signor 11583622
P55957-1 (BID) S64 HPRD   Signor 11583622
P56645-1 (PER3) S622 HPRD 11865049
P56645-1 (PER3) S625 HPRD 11865049
P56645-1 (PER3) S628 HPRD 11865049
P56645-1 (PER3) S633 HPRD 11865049
P56645-1 (PER3) S634 HPRD 11865049
P56645-1 (PER3) T635 HPRD 11865049
Q13541 (EIF4EBP1) T41 PhosphoSitePlus   Signor 24247720
Q13541 (EIF4EBP1) T50 PhosphoSitePlus   Signor 24247720
Q8TD43 (TRPM4) S839 PhosphoSitePlus 25231975
Q9BZL6 (PRKD2) S244 PhosphoSitePlus 17962809
Q9GZV5 (WWTR1) S314 Signor 24715453
Q9Y6Q9 (NCOA3) S102 PhosphoSitePlus 21577200


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K141 N141 Biomuta DOID:4159 / skin cancer [ cosmic ]
T334 M334 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S363 F363 Biomuta DOID:1324 / lung cancer [ cosmic ]
S368 P368 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S368 L368 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S389 F389 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S390 F390 Biomuta DOID:4159 / skin cancer [ cosmic ]