iPTMnet Report for P49662 (CASP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49662 / CASP4_HUMAN
Protein Name Caspase-4 precursor
Gene Name Name: CASP4
Synonyms:ICH2;
Organism Homo sapiens (Human)

PRO ID PR:P49662
DAG View
PRO Name caspase-4 (human)
Definition A caspase-4 that is encoded in the genome of human.
Short Label hCASP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49662 (CASP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S16 Phosphorylation PhosphoSitePlus
K49 Methylation PhosphoSitePlus
K53 Methylation PhosphoSitePlus
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K87 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
C109 Methylation IEDB 31844290
K129 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S83 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:363 / uterine cancer [ icgc ]
K53 E53 Biomuta DOID:3571 / liver cancer [ cosmic ]
K53 * Biomuta [ cosmic ]
K107 T107 Biomuta DOID:363 / uterine cancer [ icgc ]
S271 Y271 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T352 I352 Biomuta DOID:4159 / skin cancer [ cosmic ]