iPTMnet Report for P49615 (Cdk5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49615 / CDK5_MOUSE
Protein Name Cyclin-dependent kinase 5
Gene Name Name: Cdk5
Synonyms:Cdkn5;
Organism Mus musculus (Mouse)

PRO ID PR:P49615
DAG View
PRO Name cyclin-dependent kinase 5 (mouse)
Definition A cyclin-dependent kinase 5 that is encoded in the genome of mouse.
Short Label mCDK5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49615 (Cdk5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
Y15 Phosphorylation P39688 (Fyn) , P00520 (Abl1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21640796, 21368891, 23420105, ...19700222, 24600352, 12372285, 10896159, 33127972, 18948252
T17 Phosphorylation PhosphoSitePlus
K56 Acetylation UniProt 23806337
K56 Ubiquitination PhosphoSitePlus
T77 Phosphorylation RLIMS-P 29511352
K128 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus   RLIMS-P 14586172
K237 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus


P49615 (Cdk5) as PTM Enzyme



Substrate Site Score Source PMID
O08553 (Dpysl2) S522 RLIMS-P+ 15676027
O08599 (Stxbp1) T574 phospho.ELM 9933594
O35625 (Axin1) T480 PhosphoSitePlus 21940452, 23972596
O35927 (Ctnnd2) S300 PhosphoSitePlus 20573893
O35927 (Ctnnd2) S357 PhosphoSitePlus 20573893
O70589 (Cask) S51 PhosphoSitePlus 18054859
O70589 (Cask) S395 PhosphoSitePlus 18054859
O88643 (Pak1) T212 phospho.ELM   PhosphoSitePlus 11604394
O88809 (Dcx) S28 PhosphoSitePlus 15099191
O88809 (Dcx) S287 PhosphoSitePlus 15099191
O88809 (Dcx) T289 phospho.ELM   PhosphoSitePlus 15099191
O88809 (Dcx) S297 phospho.ELM   PhosphoSitePlus 15099191, 17482550, 14741103
O88809 (Dcx) T326 PhosphoSitePlus 15099191
O88809 (Dcx) S332 PhosphoSitePlus 15099191
O88809 (Dcx) S339 PhosphoSitePlus 15099191
O89053 (Coro1a) T418 PhosphoSitePlus 20937706
P10417 (Bcl2) S70 PhosphoSitePlus 18463240
P15209 (Ntrk2) S478 PhosphoSitePlus 17341134, 23064382
P23242 (Gja1) S279 PhosphoSitePlus 25952543
P23242 (Gja1) S282 PhosphoSitePlus 25952543
P24529 (Th) S31 phospho.ELM   PhosphoSitePlus 15471880, 15447670
P26040 (Ezr) T235 phospho.ELM   PhosphoSitePlus 12769842
P27671 (Rasgrf1) S737 PhosphoSitePlus 16921254
P28352 (Apex1) T232 PhosphoSitePlus 20473298
P31938 (Map2k1) T286 phospho.ELM   PhosphoSitePlus 11684694, 15665076
P31938 (Map2k1) T292 RLIMS-P+ 25971971
P34152-3 (Ptk2) S732 PhosphoSitePlus 12941275
P42227 (Stat3) S727 PhosphoSitePlus 15096606
P46414 (Cdkn1b) S10 PhosphoSitePlus 20810788
P46414 (Cdkn1b) T187 PhosphoSitePlus 20810788
P54227 (Stmn1) S38 PhosphoSitePlus 16925597
P97318-3 (Dab1) S246 PhosphoSitePlus 16529723
P97318-2 (Dab1) T385 PhosphoSitePlus 16529723
P97318-2 (Dab1) S400 PhosphoSitePlus 16529723
P97318-2 (Dab1) T470 PhosphoSitePlus 16529723
P97318-2 (Dab1) T476 PhosphoSitePlus 16529723
P97318-2 (Dab1) S481 PhosphoSitePlus 16529723
P97318-2 (Dab1) T484 PhosphoSitePlus 16529723
P97318-2 (Dab1) S491 PhosphoSitePlus 16529723
P97318-2 (Dab1) S515 PhosphoSitePlus 16529723
P97318 (Dab1) S524 PhosphoSitePlus 12077184
P97318-2 (Dab1) S550 PhosphoSitePlus 16529723
Q01097 (Grin2b) S1116 PhosphoSitePlus 24607229
Q01815 (Cacna1c) S783 phospho.ELM   PhosphoSitePlus 16155576
Q04735 (Cdk16) S95 phospho.ELM   PhosphoSitePlus 12084709
Q3U7R1 (Esyt1) S314 PhosphoSitePlus 19255425
Q60829 (Ppp1r1b) T75 PhosphoSitePlus 15665076, 12223474, 11572969
Q61171 (Prdx2) T89 PhosphoSitePlus 17610816
Q6P5H2 (Nes) T1554 PhosphoSitePlus 24200156
Q6PF93 (Pik3c3) T159 PhosphoSitePlus 20513426
Q6R891 (Ppp1r9b) S17 phospho.ELM   PhosphoSitePlus 15728359
Q80YE4-2 (Aatk) S34 PhosphoSitePlus 20422042
Q8BR65 (Suds3) S228 phospho.ELM 15489224
Q8R527 (Rhoq) T189 PhosphoSitePlus 18948252
Q99KH8 (Stk24) S79 PhosphoSitePlus 24872548
Q9ERR1 (Ndel1) S198 phospho.ELM   Signor 12796778
Q9ERR1 (Ndel1) T219 phospho.ELM 12796778
Q9ERR1 (Ndel1) S231 phospho.ELM   Signor 12796778
Q9ERR1 (Ndel1) S242 phospho.ELM   Signor 12796778
Q9ERR1 (Ndel1) T245 phospho.ELM 12796778
Q9ERT9 (Ppp1r1a) S67 PhosphoSitePlus 11278334
Q9WUD1 (Stub1) S20 PhosphoSitePlus 26206088


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49615 (Cdk5) Y15 P61809 (Cdk5r1) unknown eFIP 31698798
Phosphorylation P49615 (Cdk5) Y15 P00520 (Abl1) unknown eFIP 19700222