iPTMnet Report for P49591 (SARS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49591 / SYSC_HUMAN
Protein Name Serine--tRNA ligase, cytoplasmic
Gene Name Name: SARS1
Synonyms:SARS,SERS;
Organism Homo sapiens (Human)

PRO ID PR:P49591
DAG View
PRO Name serine--tRNA ligase, cytoplasmic (human)
Definition A serine--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hSARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49591 (SARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K12 Ubiquitination PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   RLIMS-P 33351793
K116 Ubiquitination PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
R157 Methylation PhosphoSitePlus
C162 Methylation IEDB 31844290
K167 Acetylation PhosphoSitePlus
K184 Acetylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S241 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 33351793
Y248 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
R317 Methylation PhosphoSitePlus
K323 Acetylation PhosphoSitePlus   UniProt 19608861
K323 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
N427 N-Glycosylation GlyGen 29741879
C431 Methylation IEDB 31844290
T436 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 34019948, 32119511, 33465208
K448 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
R505 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K28 E28 Biomuta DOID:1324 / lung cancer [ cosmic ]
K57 N57 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K99 N99 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S101 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K231 E231 Biomuta DOID:3571 / liver cancer [ cosmic ]
S255 I255 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K323 T323 Biomuta DOID:1324 / lung cancer [ cosmic ]
K323 N323 Biomuta DOID:1324 / lung cancer [ cosmic ]
S368 Y368 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]