iPTMnet Report for P49590 (HARS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49590 / SYHM_HUMAN
Protein Name Histidine--tRNA ligase, mitochondrial precursor
Gene Name Name: HARS2
Synonyms:HARSL,HARSR,HO3;
Organism Homo sapiens (Human)

PRO ID PR:P49590
DAG View
PRO Name histidine--tRNA ligase, mitochondrial (human)
Definition A histidine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hHARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49590 (HARS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
S67 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569
K76 Sumoylation PhosphoSitePlus
C84 Methylation IEDB 31844290
S127 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
K419 Acetylation PhosphoSitePlus
K444 Acetylation PhosphoSitePlus   UniProt 19608861
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231, 18707149


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K52 T52 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T59 P59 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T63 I63 Biomuta DOID:4159 / skin cancer [ cosmic ]
S67 I67 Biomuta DOID:1324 / lung cancer [ cosmic ]
S127 F127 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K377 R377 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T407 S407 Biomuta DOID:3571 / liver cancer [ cosmic ]