Protein Information

Cytoscape View


UniProt AC / UniProt ID P49589 / SYCC_HUMAN
Protein Name Cysteine--tRNA ligase, cytoplasmic
Gene Name Name: CARS
Organism Homo sapiens (Human)

PRO ID PR:P49589
DAG View
PRO Name cysteine--tRNA ligase, cytoplasmic (human)
Definition A cysteine--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hCARS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49589 (CARS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S19 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T24 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K148 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus   UniProt 24275569
S307 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K324 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K503 Acetylation PhosphoSitePlus   UniProt 19608861
K503 Ubiquitination PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K672 Acetylation PhosphoSitePlus
S746 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation HPRD 20068231
T239 Phosphorylation HPRD 20068231
Y260 Phosphorylation HPRD 15592455
S307 Phosphorylation HPRD 19664994, 20068231
S746 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation HPRD 20068231
K48 Acetylation PhosphoSitePlus
T239 Phosphorylation HPRD 20068231
Y260 Phosphorylation HPRD   PhosphoSitePlus 15592455
S307 Phosphorylation HPRD 19664994, 20068231
S706 Phosphorylation PhosphoSitePlus
K717 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S117 Phosphorylation HPRD 20068231
K131 Acetylation PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
T322 Phosphorylation HPRD 20068231
Y343 Phosphorylation HPRD   PhosphoSitePlus 15592455
S390 Phosphorylation HPRD 19664994, 20068231
Y527 Phosphorylation PhosphoSitePlus
S829 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T36 S36 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K48 E48 Biomuta DOID:1909 / melanoma [ cosmic ]
Y53 H53 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y260 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S305 I305 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K412 Q412 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]