iPTMnet Report for P49585 (PCYT1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49585 / PCY1A_HUMAN
Protein Name Choline-phosphate cytidylyltransferase A
Gene Name Name: PCYT1A
Synonyms:CTPCT,PCYT1;
Organism Homo sapiens (Human)

PRO ID PR:P49585
DAG View
PRO Name choline-phosphate cytidylyltransferase A (human)
Definition A choline-phosphate cytidylyltransferase A that is encoded in the genome of human.
Short Label hPCYT1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49585 (PCYT1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K8 Acetylation PhosphoSitePlus   UniProt 19608861
K8 Sumoylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus   UniProt 23186163
K238 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K266 Sumoylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S315 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 23186163, 17081983, ...18691976, 18767875, 20058876, 19415658, 17322306, 18669648, 15788406, 19651622, 19690332, 20068231, 18212344
S319 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18669648, 19690332
S321 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 17081983
S322 Phosphorylation PhosphoSitePlus
S323 Phosphorylation HPRD   PhosphoSitePlus 17081983
T325 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983
S329 Phosphorylation HPRD   IEDB   PhosphoSitePlus 17081983, 35561310, 27920218, ...20068231, 27869121
S331 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231, ...19664995
S333 Phosphorylation PhosphoSitePlus
S339 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T342 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18767875, ...19664995, 18669648, 16964243
S343 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18212344, ...19664995, 17322306, 18669648, 24275569, 19690332, 20068231
S347 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 23186163, ...16964243, 19664995, 17322306, 18669648, 24275569, 19690332, 20068231, 18212344
S352 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y359 Phosphorylation HPRD   PhosphoSitePlus 17322306
S362 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 16964243, ...18767875, 19415658, 19651622, 17322306, 18669648, 24275569, 19690332, 20068231, 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 M8 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y173 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K186 E186 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K261 N261 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S322 R322 Biomuta DOID:1324 / lung cancer [ cosmic ]
S329 Y329 Biomuta DOID:4159 / skin cancer [ cosmic ]
S329 P329 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S331 F331 Biomuta [ cosmic ]
S347 F347 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]