iPTMnet Report for P49459 (UBE2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49459 / UBE2A_HUMAN
Protein Name Ubiquitin-conjugating enzyme E2 A
Gene Name Name: UBE2A
Synonyms:RAD6A;
Organism Homo sapiens (Human)

PRO ID PR:P49459
DAG View
PRO Name ubiquitin-conjugating enzyme E2 A (human)
Definition A ubiquitin-conjugating enzyme E2 A that is encoded in the genome of human.
Short Label hUBE2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49459 (UBE2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
C88 Methylation IEDB 31844290
S120 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22592529, 11953320
S120 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 11953320
S120 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor 11953320
S142 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S120 Phosphorylation HPRD 11953320
S120 Phosphorylation P06493 (CDK1) HPRD 11953320
S120 Phosphorylation P24941 (CDK2) HPRD 11953320
Site PTM Type PTM Enzyme Score Source PMID
S90 Phosphorylation HPRD 11953320
S90 Phosphorylation P06493 (CDK1) HPRD 11953320
S90 Phosphorylation P24941 (CDK2) HPRD 11953320


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C88 R88 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S142 F142 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]