iPTMnet Report for P49450 (CENPA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49450 / CENPA_HUMAN
Protein Name Histone H3-like centromeric protein A
Gene Name Name: CENPA
Organism Homo sapiens (Human)

PRO ID PR:P49450
DAG View
PRO Name histone H3-like centromeric protein A (human)
Definition A histone H3-like centromeric protein A that is encoded in the genome of human.
Short Label hCENPA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49450 (CENPA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Methylation UniProt 26543159, 23818633
S7 Phosphorylation PR:000035365 (aurora kinase) , Q96GD4 (AURKB) , O14965 (AURKA) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23890477, 15108802, 30635586, ...19714251, 11756469, 18239465, 20643881, 30892990, 24917673, 15592459, 14667408, 29760389
S17 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 23818633, ...18669648, 24275569
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 23818633, ...18669648, 24275569
T21 Phosphorylation PhosphoSitePlus
T23 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S27 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S32 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S68 Phosphorylation P06493 (CDK1) PhosphoSitePlus   RLIMS-P   UniProt 28073008, 25556658
T120 Phosphorylation IEDB 35494241
K124 Acetylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation Q96GD4 (AURKB) HPRD 11756469
S17 Phosphorylation HPRD 19651622, 18669648, 17081983
S19 Phosphorylation HPRD 19651622, 18669648, 17081983
T21 Phosphorylation HPRD 19651622
T23 Phosphorylation HPRD 18669648, 17081983
S27 Phosphorylation HPRD 19651622, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation HPRD 19651622, 18669648, 17081983
S19 Phosphorylation HPRD 19651622, 18669648, 17081983
T21 Phosphorylation HPRD 19651622
T23 Phosphorylation HPRD 18669648, 17081983
S27 Phosphorylation HPRD 19651622, 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035364 (hCENPA/InitMet-/Phos:1) pS7 PR:000035365 (aurora kinase) PRO 11756469, 14667408, 15592459


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49450 (CENPA) S68 Q8NCD3 (HJURP) unknown eFIP 29479426


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P49450 (hCENPA) Interaction PR:Q96GD4 (hAURKB) PRO
PR:P49450 (hCENPA) Interaction PR:P68431 (hH3.1) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 F32 Biomuta DOID:1319 / brain cancer [ cosmic ]
R42 Q42 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R42 W42 Biomuta DOID:4159 / skin cancer [ cosmic ]
S68 N68 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]