iPTMnet Report for P49448 (GLUD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49448 / DHE4_HUMAN
Protein Name Glutamate dehydrogenase 2, mitochondrial precursor
Gene Name Name: GLUD2
Synonyms:GLUDP1;
Organism Homo sapiens (Human)

PRO ID PR:P49448
DAG View
PRO Name glutamate dehydrogenase 2, mitochondrial (human)
Definition A glutamate dehydrogenase 2, mitochondrial that is encoded in the genome of human.
Short Label hGLUD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49448 (GLUD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y53 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
R76 Methylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
C112 S-Nitrosylation dbSNO 24105792
S117 O-Glycosylation GlyGen 35254053
S128 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
K171 Methylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
K346 Acetylation PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K390 Acetylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
K415 Acetylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
K527 Acetylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
K545 Acetylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 P12 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S12 Y12 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y53 N53 Biomuta DOID:1324 / lung cancer [ cosmic ]
S54 C54 Biomuta DOID:1319 / brain cancer [ cosmic ]
R76 H76 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R76 C76 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
C112 Y112 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S128 P128 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S128 Y128 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y135 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S153 N153 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T154 I154 Biomuta DOID:363 / uterine cancer [ icgc ]
S157 T157 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S316 P316 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K346 T346 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K346 N346 Biomuta DOID:363 / uterine cancer [ icgc ]
S357 F357 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K390 N390 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y439 N439 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y439 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y451 F451 Biomuta DOID:363 / uterine cancer [ icgc ]
T524 A524 Biomuta DOID:4159 / skin cancer [ cosmic ]
K527 T527 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y528 H528 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y528 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]